Biphasic effect of alcohol intake on the development of fatty liver disease

Journal of Gastroenterology
Hirokazu TakahashiYuichiro Eguchi

Abstract

Fatty liver is an important clinical feature not only in alcoholic and non-alcoholic fatty liver diseases, but in other chronic liver diseases as well. Our aim was to elucidate the effect and relationship between habitual alcohol intake and obesity in the development of fatty liver disease. We enrolled 8,029 subjects undergoing abdominal ultrasonography with general medical examinations, and analyzed the factors associated with fatty liver based on daily alcohol intake, body mass index (BMI), and waist circumference. For fatty liver, BMI, waist circumference, total cholesterol, triglycerides, and fasting plasma glucose were significant and independent risk factors. Heavy alcohol intake (50 g/day) was a significant risk factor for fatty liver in women (odds ratio [OR], 3.35). Analysis based on the presence or absence of obesity revealed that moderate alcohol intake was a significant negative risk factor for fatty liver in both male and female obese (BMI ≥25 kg/m(2)) subjects (OR, 0.74 for non-obese and 0.39 for obese patients, respectively). Heavy alcohol intake was also a significant negative risk factor in obese males (0.62). In contrast, heavy alcohol intake was a risk factor in non-obese males (OR, 1.29) and in all females (...Continue Reading

References

Mar 1, 1991·Biochemical Pharmacology·C M Yang, G P Carlson
Jan 1, 1988·The American Journal of Physiology·A GéloënL J Bukowiecki
Nov 1, 1985·The Journal of Clinical Endocrinology and Metabolism·H Yki-Järvinen, E A Nikkilä
Sep 1, 1968·The American Journal of Digestive Diseases·C L Mendenhall
May 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·U BeckerG Jensen
Jan 22, 2000·Annals of Internal Medicine·S BellentaniC Tiribelli
Nov 7, 2002·Circulation Journal : Official Journal of the Japanese Circulation Society·UNKNOWN Examination Committee of Criteria for 'Obesity Disease' in Japan, UNKNOWN Japan Society for the Study of Obesity
Dec 6, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Maria P GuarinoM Paula Macedo
Apr 3, 2003·Biochemical and Biophysical Research Communications·Yukiko OnishiTomoichiro Asano
Nov 10, 2004·Clinical Psychology Review·Susan Nolen-Hoeksema
Jan 28, 2005·European Journal of Gastroenterology & Hepatology·Loreta A KondiliBashkim Resuli
Apr 21, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Gaspare Maria PendinoUNKNOWN ACE Collaborating Group
May 26, 2005·Life Sciences·Daniela Tomie FuruyaUbiratan Fabres Machado
Dec 20, 2005·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Constance E Ruhl, James E Everhart
Nov 7, 2006·Nature·Joseph A BaurDavid A Sinclair
May 19, 2007·The American Journal of Gastroenterology·Ayako SuzukiKeith Lindor
Aug 10, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Giorgio BedogniStefano Bellentani
Dec 18, 2007·World Journal of Gastroenterology : WJG·Yong-Jian ZhouPin-Jin Hu
May 6, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Winston DunnJeffrey B Schwimmer
Oct 1, 2009·Journal of Gastroenterology·Kojiro MichitakaUNKNOWN Japan Etiology of Liver Cirrhosis Study Group
Nov 12, 2009·The American Journal of Gastroenterology·Robert S O'SheaArthur J McCullough
Oct 23, 2010·Journal of Gastroenterology·Yasunari HiramineHirohito Tsubouchi
Feb 1, 2013·Science Translational Medicine·Claudia LindtnerChristoph Buettner
Oct 16, 2013·Atherosclerosis·E Lopez-GarciaF Rodriguez-Artalejo
Jan 1, 2014·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Kenichi TanakaUNKNOWN Japan Study Group of Non-alcoholic Fatty Liver Disease (JSG-NAFLD)

❮ Previous
Next ❯

Citations

Sep 8, 2015·Experimental and Molecular Pathology·Manuela G NeumanSamuel W French
Jul 5, 2016·Clinics in Liver Disease·Christine C Hsu, Kris V Kowdley
Sep 8, 2015·Journal of Clinical Lipidology·Piers R BlackettCatherine J McNeal
Jan 19, 2016·Gastroenterology·Silvia Sookoian, Carlos J Pirola
May 10, 2016·World Journal of Gastrointestinal Pharmacology and Therapeutics·Shingo ArakakiJiro Fujita
Oct 28, 2018·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Kenichi TanakaYuichiro Eguchi
Jun 21, 2019·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Nooshin HosseiniGyongyi Szabo
Sep 18, 2016·Journal of Gastroenterology·Wai-Kay Seto, Man-Fung Yuen
Dec 20, 2019·Alcoholism, Clinical and Experimental Research·Fredrik ÅbergVille Männistö
Aug 21, 2019·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Ryoko TajimaKaoruko Iida
Dec 6, 2020·Mayo Clinic Proceedings·Thoetchai Bee PeeraphatditVijay H Shah
Sep 16, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Aya SugiyamaJunko Tanaka

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban
Jiaoyue ZhangTing Chen
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
Song-ming DuYong-hua Hu
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
K MatsuuraT Tsuji
© 2022 Meta ULC. All rights reserved