PMID: 9169295May 1, 1997Paper

Biphasic effects of 8-OH-DPAT on endurance of treadmill performance in the male rat

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
S AhleniusP Salmi

Abstract

Administration of the 5-HT1A receptor agonist 8-OH-DPAT produced a biphasic pattern of effects on endurance performance of rats walking on top of a treadmill drum ([symbol: see text] = 166 mm, 16 rpm; approximately 8 m min-1), with enhanced performance at a low dose (0.1 mg kg-1 s.c.) followed by impairment (0.2-0.8 mg kg-1). The partial 5-HT1A receptor agonist (-)-pindolol improved the performance in the low dose range (0.5-2.0 mg kg-1 s.c.), whereas a higher dose (8 mg kg-1) was ineffective. The 5-HT1A receptor antagonist WAY-100,635 produced an impaired performance at a low dose (12.5 micrograms kg-1 s.c.), with a recovery of performance at higher doses (50-200 micrograms kg-1). It is suggested that the inhibition of central serotonergic neurotransmission produced by stimulation or blockade of 5-HT1A auto- and post-synaptic receptors, respectively, results in an improved endurance performance on the treadmill, whereas stimulation of postsynaptic 5-HT1A receptors has the opposite action. In support of this contention, the impaired performance produced by a high dose of 8-OH-DPAT (0.8 mg kg-1) was antagonized by pretreatment with (-)-pindolol (2 mg kg-1 s.c.).

References

May 1, 1992·Acta Physiologica Scandinavica·S P BaileyE N Ahlborn
Feb 28, 1991·The New England Journal of Medicine·J M Astrachan
Mar 1, 1989·Pharmacology, Biochemistry, and Behavior·V HillegaartS Ahlenius
May 1, 1989·Naunyn-Schmiedeberg's Archives of Pharmacology·S AhleniusA Wijkström
Sep 1, 1989·Acta Physiologica Scandinavica·F Chaouloff
Nov 1, 1985·Neuropharmacology·S Hjorth, A Carlsson
Aug 1, 1993·International Journal of Sports Medicine·S P BaileyE N Ahlborn
Jul 25, 1995·European Journal of Pharmacology·E A ForsterA Fletcher

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Citations

Apr 5, 2003·The Journal of Applied Psychology·Joyce Hogan, Brent Holland
Mar 27, 2003·Psychopharmacology·Sara D McKenzie-Quirk, Klaus A Miczek
Sep 9, 2017·Journal of Applied Physiology·Patrícia C R RabeloDanusa D Soares

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