Biphasic effects of amphetamine on striatal dopamine dynamics

European Journal of Pharmacology
R Kuczenski

Abstract

S(+)-Amphetamine (AMPH) was administered to rats over the dose range 0.15-10.0 mg/kg (1.74(3)mumoles/kg) at various times before sacrifice. 15 min before sacrifice rats received an intraventricular injection of 3H-tyrosine, and the accumulation of striatal 3H-dopamine (DA) was assessed as an index of striatal DA formation and utilization. 3H-DA formation exhibited a biphasic dose response to AMPH. At 16 and 31 min after AMPH administration, 3H-DA accumulation increased linearly in response to AMPH to a maximal rate of 200% of control values at 1.0 mg/kg, then declined to less than 50% of control values at AMPH doses of 5 and 10 mg/kg. As a function of time, low doses of AMPH (to 2.0 mg/kg)) only increased 3H-DA accumulation, whereas high doses of AMPH (greater than 2.5 mg/kg) only decreased 3H-DA accumulation. All doses of AMPH increased endogenous levels of striatal DA. The data are discussed in terms of compensatory adaptive mechanisms of the nigrostriatal dopaminergic pathway.

References

Nov 7, 1975·Science·P M GrovesG V Rebec
Jun 1, 1976·European Journal of Pharmacology·B H Westerink, J Korf
Aug 1, 1976·European Journal of Pharmacology·C Braestrup, J Scheel-Krüger
Feb 1, 1975·European Journal of Pharmacology·R Kuczenski, D S Segal
Nov 1, 1975·European Journal of Pharmacology·M RaiteriG Levi
Sep 1, 1973·The Journal of Pharmacy and Pharmacology·J E Harris, R J Baldessarini
Mar 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·M J BessonJ Glowinski
Oct 1, 1969·The Journal of Pharmacy and Pharmacology·A Jori, D Bernardi
Sep 1, 1972·The Journal of Pharmacy and Pharmacology·W KehrC Atack
Apr 1, 1972·British Journal of Pharmacology·E CostaM K Naimzada
Jul 1, 1973·European Journal of Pharmacology·F A WieselG Sedvall
Feb 1, 1972·European Journal of Pharmacology·J A Fuentes, J Del Rio
Jul 1, 1972·British Journal of Pharmacology·R J BoakesJ M Candy
Oct 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·A S Horn, S H Snyder
Jan 1, 1970·European Journal of Pharmacology·N E AndénU Ungerstedt
Sep 1, 1967·European Journal of Pharmacology·H CorrodiT Hökfelt
Jun 1, 1965·British Journal of Pharmacology and Chemotherapy·R LAVERTY, D F SHARMAN

Citations

Nov 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·K SvenssonA Carlsson
Jul 18, 1989·European Journal of Pharmacology·Y L Hurd, U Ungerstedt
Sep 1, 1981·Pharmacology, Biochemistry, and Behavior·R Kuczenski, N J Leith
Sep 1, 1982·Pharmacology, Biochemistry, and Behavior·J D SalamoneJ B Justice
Sep 1, 1982·Journal of Pharmacological Methods·C H Cheng, G F Wooten
Jan 16, 2020·Current Pharmaceutical Design·Branka PetkovićVesna Pešić

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