Biphasic elevation of bilirubin oxidation during myocardial ischemia reperfusion

Circulation Journal : Official Journal of the Japanese Circulation Society
Masaki YamamotoS Sasaguri

Abstract

The time course of oxidative stress involving nitric oxide (NO) after myocardial ischemia reperfusion (MIR) has not been elucidated in detail, so the present study was designed to assess the dynamics of oxidative stress after MIR, urinary excretion of oxidized bilirubin metabolites (ie, biopyrrins) and their generation in various organs. Rat models of MIR were created by occluding the left coronary artery for 30 min followed by 48 h of reperfusion. Levels of urinary biopyrrins increased biphasically at 8 h and 24 h after MIR. Biopyrrins were upregulated in the lungs at 8 h after MIR, according to immunohistochemistry and ELISA, and at 24 h biopyrrin expression was increased in the heart and lungs. The NO synthase inhibitor, NG-monomethyl-L-arginine, significantly diminished biopyrrin synthesis in the heart and lungs at 24 h, but not in the lungs at 8 h after MIR. Hemodynamic assessment revealed increased left ventricle end-diastolic pressure, suggesting that lung congestion influences pulmonary biopyrrin formation. The dynamics of urinary biopyrrins might reflect earlier biopyrrin generation in the lungs and delayed formation in both the lungs and heart when NO is involved. Therefore, urinary biopyrrins can serve as a useful ma...Continue Reading

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Citations

Jan 9, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Dong-Hyeon LeeHae Kyung Lee
Dec 9, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Eiji Oda, Ryu Kawai
Jun 9, 2017·Circulation Journal : Official Journal of the Japanese Circulation Society·Masaki YamamotoKazumasa Orihashi

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