Biphasic hydroxyapatite and ß-tricalcium phosphate biomaterial behavior in a case series of maxillary sinus augmentation in humans

Clinical Oral Implants Research
Allinson OlaecheaPablo Galindo-Moreno

Abstract

The aim of this study was to evaluate and compare the morphometric components and the histological properties of pristine bone and bone grafted with a biphasic ß-tricalcium phosphate in humans using the maxillary sinus model. Reparative mesenchymal stem cells in the pristine bone and graft were also evaluated. For this prospective case series, sinus augmentation was performed using a biphasic ß-tricalcium phosphate. After 6 months of healing, a core of remnant native alveolar bone and grafted bone was collected with a trephine. Histological, histomorphometrical, and immunohistochemical techniques were performed. Radiological analysis through cone beam computerized tomography was also conducted. A total of 10 patients were enrolled in this study. Radiologically, patients showed an average increase of crestal bone of 8.03 ± 1.72 mm. Morphologically, the grafted area was composed by 34.93 ± 14.68% of new mineralized tissue, 9.82 ± 11.42% of remnant biomaterial particles, and 55.23 ± 11.03% non-mineralized tissue. Histologically, we found no differences in the number of osteocytes per mm2 (p = 0.674), osteoblasts (p = 0.893), and blood vessels (p = 0.894) in the grafted area compared to the pristine bone. Differences were found on ...Continue Reading

References

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Jan 27, 2017·Implant Dentistry·Miguel Velasco-TorresPablo Galindo-Moreno
Aug 18, 2018·Scientific Reports·Francisco O'VallePablo Galindo-Moreno
Dec 18, 2018·Clinical Implant Dentistry and Related Research·Danielle ClarkLiran Levin

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Citations

May 6, 2019·International Journal of Molecular Sciences·Miguel Padial-MolinaPablo Galindo-Moreno
Sep 7, 2019·Biomedical Materials·Rui GeYuancheng Li
Apr 4, 2021·International Journal of Molecular Sciences·Miguel Padial-MolinaFrancisco O'Valle

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