Biphasic insulin aspart 30 treatment in patients with type 2 diabetes poorly controlled on prior diabetes treatment: results from the PRESENT study

Current Medical Research and Opinion
S K SharmaJ A Vaz

Abstract

The safety and efficacy of biphasic insulin aspart (BIAsp30) were evaluated in patients uncontrolled on previous treatment (human insulin +/- oral hypoglycaemic agent [OHA] or OHA only) in routine clinical practice. This was a large, multi-national, multicentre, prospective, 6-month study in type 2 diabetes mellitus patients who were prescribed BIAsp30. Changes in glycated haemoglobin (HbA(1c)), fasting plasma glucose (FPG), postprandial plasma glucose (PPPG), proportion who achieved target HbA(1c) < 7% and rate of hypoglycaemic episodes were assessed. This paper evaluates outcomes in patients by diabetes duration (< 5, 5-10, 10-20 or >/= 20 years) stratified by prior therapy. After 6 months of treatment, glycaemia improved significantly across the duration subgroups. The improvement was better in insulin-naïve group versus prior insulin group: HbA(1c) decreased approximately 2.2%-points versus approximately 1.6%-points, FPG decreased approximately 4.5 mmol/L versus approximately 2.9 mmol/L and PPPG decreased approximately 6.8 mmol/L versus approximately 5.0 mmol/L. Target HbA(1c) was achieved by about one in four patients although insulin-naïve patients achieved this at comparatively lower BIAsp30 dose. Body weight remained re...Continue Reading

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Citations

Jul 19, 2013·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Mohammad Ebrahim KhamsehMohammad Imtiaz Hasan
Jan 1, 2009·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Paul Valensi
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Jul 10, 2010·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Kyoung Hee LeeWilliam J Valentine
Jun 29, 2013·Diabetes & Metabolism Journal·Hye Jin YooSei Hyun Baik
Nov 21, 2018·Diabetes, Obesity & Metabolism·Ulrik Pedersen-BjergaardKamlesh Khunti

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