Biphasic, organ-specific, and strain-specific accumulation of platelets induced in mice by a lipopolysaccharide from Escherichia coli and its possible involvement in shock.

Infection and Immunity
M ShibazakiY Endo

Abstract

Platelets contain a large amount of 5-hydroxytryptamine (5HT, serotonin). Intravenous injection into BALB/c mice of a Boivin's preparation of lipopolysaccharide (LPS) from Escherichia coli induced rapid 5HT accumulation in the lung (within 5 min) and slow 5HT accumulation in the liver (2 to 5 h later). The rapid response required high doses of LPS (more than 0.1 mg/kg). On the basis of 5HT measurements, 70% or more of the platelets which disappeared from the blood appeared to have accumulated rapidly in the lung, and a large number of platelets were found there by electron microscopy. A shock, which was manifested by crawling, convulsion, or prostration, followed shortly after the rapid accumulation of 5HT in the lung. On the other hand, the slow accumulation of 5HT in the liver could be induced by much lower doses of LPS (1 microg/kg or less), even when given by intraperitoneal injection. This 5HT accumulation appears to be a reflection of platelet accumulation in the liver (Y. Endo and M. Nakamura, Br. J. Pharmacol. 105:613-619, 1992). The combination of a low dose of LPS with D-galactosamine amplified the hepatic accumulation of 5HT, and the mice developed a severe hepatic congestion resulting in death. The rapid response wa...Continue Reading

References

Nov 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·C GalanosW Reutter
Feb 1, 1990·Journal of Medical Microbiology·H F DingH S Hsu
Jul 1, 1950·Proceedings of the Society for Experimental Biology and Medicine·L WISHR H STOREY

❮ Previous
Next ❯

Citations

Nov 25, 2003·Hematology·Theodore E WarkentinJacob H Rand
May 17, 2000·The Journal of Experimental Medicine·Y ChvatchkoC A Power
Jun 18, 2005·Blood·Graciela AndoneguiPaul Kubes
Feb 19, 2008·British Journal of Haematology·Fabrice CognasseOlivier Garraud
Jan 4, 2012·Journal of Thrombosis and Haemostasis : JTH·C LecutC Oury
May 25, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Zbigniew MikulskiWolfgang Kummer
May 3, 2013·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Jie LinXuechun Lu
Dec 18, 2019·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Elizabeth W J KerrisRobert J Freishtat
Jan 13, 2009·American Journal of Respiratory and Critical Care Medicine·Robert J FreishtatEric P Hoffman
Aug 6, 2019·Frontiers in Immunology·Alice AssingerJulie Rayes
Mar 25, 2017·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Jeffrey E GottsMichael A Matthay
Jun 3, 2021·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Kanan BandoYasuo Endo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.