PMID: 6976144Jan 1, 1982Paper

Biphasic pattern of bacterial infection in multiple myeloma

Annals of Internal Medicine
D G SavageT J Garrett

Abstract

Since the 1960s, gram-negative bacilli have become commoner pathogens than Streptococcus pneumoniae in multiple myeloma. To investigate this trend, we analyzed 75 bacterial infections in 57 patients with myeloma. Episodes of infection with Streptococcus pneumoniae and Haemophilus influenzae occurred at presentation, early in the disease, and in patients responding to chemotherapy. Gram-negative bacilli and Staphylococcus aureus caused 80% of infections seen after diagnosis and 92% of deaths from infection. Episodes of infection with gram-negative bacteria occurred in patients with active and advancing disease and in those responding to chemotherapy when neutropenia. Impaired antibody production may be the major immune defect leading to S. pneumoniae and H. influenzae infections whereas some additional factor or factors related to disease activity appear to predispose to gram-negative infection in myeloma.

Citations

Jan 1, 1990·Cancer Immunology, Immunotherapy : CII·H J NielsenA Drivsholm
Oct 1, 1989·The American Journal of Medicine·J J ZurloL F Fries
Apr 30, 2003·European Journal of Internal Medicine·Olivier LambotteJean Paul Fermand
Jan 5, 2011·International Journal of Rheumatic Diseases·Shan-Fu YuTien-Tsai Cheng
Mar 1, 1995·Journal of Clinical Pathology·R M HargreavesH M Chapel
Jan 28, 2014·International Journal of Medical Microbiology : IJMM·Barbara M BrökerIsabelle Bekeredjian-Ding
Jan 1, 1984·Scandinavian Journal of Infectious Diseases·F EspersenA Drivsholm
Mar 1, 1991·Chest·R S McKenzieJ C Goldsmith
Jul 28, 2015·American Journal of Hematology·Wilson I GonsalvesLuciano J Costa
May 24, 2011·Seminars in Oncology·Bernardo Leon Rapoport
Jan 30, 2010·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Sadaya MatanoTatsuho Sugimoto
Jun 25, 2009·Seminars in Hematology·Marcio Nucci, Elias Anaissie
Apr 14, 2006·Mayo Clinic Proceedings·Daniel B Costa
Nov 13, 2007·Hematology/oncology Clinics of North America·Joan Bladé, Laura Rosiñol
Jun 3, 2009·International Journal of Laboratory Hematology·G N KalambokisE V Tsianos
Aug 10, 2007·British Journal of Haematology·Guy PrattPaul Moss
Jan 18, 2006·British Journal of Haematology·Alastair SmithUNKNOWN British Committee for Standards in Haematology
Apr 27, 2011·British Journal of Haematology·John A SnowdenUNKNOWN Haemato-oncology Task Force of British Committee for Standards in Haematology and UK Myeloma Forum
Sep 27, 2012·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Maja HingeIngolf Mølle
Feb 11, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A A KhanS Warnakulasuriya
Jun 18, 2014·American Journal of Physical Anthropology·Katherine van SchaikFrank Rühli
Jul 1, 1993·Disease-a-month : DM·A S Rosenberg, A E Brown
May 15, 1984·The American Journal of Medicine·P K Peterson
May 15, 1984·The American Journal of Medicine·J N Sheagren
Dec 1, 1995·Baillière's Clinical Haematology·M A DimopoulosP Athanassiades
Jan 1, 1983·Journal of the American Geriatrics Society·T T Yoshikawa
Jul 20, 2005·Best Practice & Research. Clinical Haematology·Angela Dispenzieri, Robert A Kyle
Jul 20, 2005·Best Practice & Research. Clinical Haematology·Joan Bladé, Laura Rosiñol
Jul 13, 2001·Infectious Disease Clinics of North America·F ParadisiR Cinelli
Aug 30, 2001·Critical Care Clinics·A Safdar, D Armstrong
Dec 12, 2013·Journal of Cardiothoracic and Vascular Anesthesia·Samarjit BisoyiBrajaraj Dash
Jul 13, 2016·Hematological Oncology·Vanda FrimanFatima Dhalla
Oct 8, 2016·European Journal of Haematology·Benjamin W TehLeon J Worth
Mar 29, 2000·Annals of Emergency Medicine·S HarbickA J Cummings
Oct 21, 2004·American Journal of Hematology·Daniel B CostaDennis L Cooper
Feb 23, 2019·Journal of the National Comprehensive Cancer Network : JNCCN·Erin ReidDeborah A Freedman-Cass
Jun 9, 2012·Leukemia·D H VesoleUNKNOWN University of Rochester Cancer Center and the Eastern Cooperative Oncology Group

❮ Previous
Next ❯

Related Concepts

Related Feeds

CRISPR & Staphylococcus

CRISPR-Cas system enables the editing of genes to create or correct mutations. Staphylococci are associated with life-threatening infections in hospitals, as well as the community. Here is the latest research on how CRISPR-Cas system can be used for treatment of Staphylococcal infections.

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.