Abstract
The objective of this systematic meta-analysis was to study the impact of icodextrin (ICO) on lipid profiles. MEDLINE, PubMed, Embase, Chinese Biomedical Literature, and the Cochrane Library and Reference lists were searched (last search September 2014) in accordance with the Cochrane Handbook for Systematic Reviews of Interventions. Searches identified 13 eligible trials with a total of 850 patients. The differentials of total cholesterol (TC) and free fatty acid (FFA) in the ICO group were greater than those in the GLU group. Metaregression analysis showed that TC levels positively correlated with its baseline levels. In the subgroup of patients with dialysis duration more than 6 months, TC and TG in the ICO group were less. In pooled data from cross-sectional studies, differential of TG in the ICO group was less. In the subgroup of patients with diabetes (Martikainen et al., 2005, Sniderman et al., 2014, and Takatori et al., 2011), differential of high-density lipoprotein cholesterol (HDL-C) in the ICO group was less. There was no significant effect on low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), or lipoprotein(a). ICO may be beneficial to lipid metabolism, especially for it...Continue Reading
References
Nov 20, 1998·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R N FoleyM J Sarnak
Jun 17, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Koen J M van HoeckCornelis H Schroder
Mar 12, 2004·Nephrology·David W JohnsonMichael Suranyi
Jan 22, 2005·Seminars in Dialysis·John Burkart
Jun 28, 2005·Blood Purification·Terhi MartikainenAgneta Ekstrand
Oct 14, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ryuichi FuruyaAkira Hishida
Jun 1, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Arsalan N HabibAlexander S Goldfarb-Rumyantzev
Dec 26, 2006·Trends in Parasitology·Osamu Kunii
May 15, 2007·Renal Failure·Mustafa Canbakan, Gülizar Manga Sahin
May 15, 2007·Renal Failure·M KanbayR Yigitoglu
Jul 20, 2007·Nephrology·David W JohnsonNicole M Isbel
Aug 7, 2007·Health and Quality of Life Outcomes·Ai-Hua ZhangTao Wang
Feb 28, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Philip Kam-Tao Li, Cheuk-Chun Szeto
May 3, 2008·Kidney International. Supplement·S G JohnC W McIntyre
Oct 8, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Aiwu LinUNKNOWN Icodextrin National Multi-center Cooperation Group
Nov 12, 2009·JAMA : the Journal of the American Medical Association·UNKNOWN Emerging Risk Factors CollaborationJohn Danesh
Feb 11, 2010·Journal of Diabetes Science and Technology·Clifford J Holmes
Jun 23, 2010·Nature Reviews. Nephrology·Raymond T Krediet, Olga Balafa
Sep 30, 2010·Archives of Internal Medicine·Rajnish MehrotraEdward Vonesh
Apr 16, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Yuji TakatoriHirofumi Makino
Apr 23, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Uyen DuongKamyar Kalantar-Zadeh
May 25, 2011·Journal of Nephrology·Hamad DheirErcan Ok
Apr 2, 2013·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Marcin BarylskiUNKNOWN Lipid and Blood Pressure Meta-Analysis Collaboration Group
Sep 11, 2013·International Journal of Cardiology·Dragana NikolicUNKNOWN Lipid and Blood Pressure Meta-Analysis Collaboration Group
Oct 29, 2013·BMC Nephrology·Eiichiro KandaMasayuki Yoshida
Aug 12, 2014·Journal of Clinical Lipidology·Allan D SnidermanJoanne M Bargman
Mar 12, 2015·International Urology and Nephrology·Jacek RyszAndrzej Więcek