PMID: 8613640Mar 1, 1996Paper

Biphasic response against aeroallergen in atopic dermatitis showing a switch from an initial TH2 response to a TH1 response in situ: an immunocytochemical study

The Journal of Allergy and Clinical Immunology
T ThepenC A Bruijnzeel-Koomen

Abstract

In the pathogenesis of atopic dermatitis (AD), IgE plays an important role; and TH2 cells, producing IL-4, have been ascribed a key role in allergic diseases such as AD. To investigate the role of TH subpopulations in the onset and continuation of AD, we performed atopy patch tests (APTs) with house dust mite allergen in patients with AD. Punch biopsy specimens were taken from the APT site, and sections were immunocytochemically double-stained for IL-4 and interferon-gamma together with different membrane markers. This provides a unique model for studying the kinetics of the TH0, TH1, and TH2 responses in situ. The results show that in lesional skin interferon-gamma-positive cells predominate over IL-4-positive cells. The interferon-gamma-positive cells are mainly CD3+ and, in particular, CD4+ cells; the remainder are CD8+, RFD-1+, and RFD-7+ cells. The IL-4-positive cells are exclusively CD4+ T cells; no eosinophils or mast cells were found to stain for IL-4. With regard to the TH cell response, a clear dichotomy of the eczematous response to allergen in skin was observed. In the initiation phase IL-4 production by TH2 and TH0 cells is predominant over interferon-gamma production by TH1 and TH0 cells. In the late and chronic p...Continue Reading

Citations

Nov 28, 2000·European Journal of Immunology·M AkdisC A Akdis
Feb 10, 2000·Springer Seminars in Immunopathology·T Biedermann, M Röcken
Mar 27, 2013·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Guangchen SunYingqin Liu
Jun 12, 2009·Human Genetics·Ulla ChristensenAnders D Børglum
Mar 16, 2002·Current Allergy and Asthma Reports·Mübeccel AkdisCezmi A Akdis
Jun 5, 2002·Current Allergy and Asthma Reports·Donald Rudikoff
Aug 11, 2006·Current Allergy and Asthma Reports·Peck Y Ong, Donald Y M Leung
Jan 15, 2009·Immunology and Allergy Clinics of North America·Soma JyonouchiJonathan M Spergel
May 12, 2004·International Immunopharmacology·Mohammad Reza Namazi
Oct 6, 2001·Veterinary Immunology and Immunopathology·T J NuttallP B Hill
Jun 20, 2002·Veterinary Immunology and Immunopathology·J D SinkeT Willemse
Jun 20, 2002·Veterinary Immunology and Immunopathology·T J NuttallP B Hill
Jun 29, 2002·Veterinary Immunology and Immunopathology·Sadatoshi MaedaHajime Tsujimoto
Dec 3, 2002·Veterinary Immunology and Immunopathology·Sadatoshi MaedaHajime Tsujimoto
Jun 1, 1997·Veterinary Immunology and Immunopathology·J D SinkeT Willemse
Feb 24, 2000·International Journal of Immunopharmacology·T SengokuT Goto
Jun 5, 2003·Clinics in Dermatology·Nordwig S Tomi, Thomas A Luger
Apr 23, 2003·Clinics in Dermatology·Arash Akhavan, Steven R Cohen
Dec 5, 2000·Current Opinion in Immunology·C A AkdisK Blaser
Jun 11, 2005·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Ozlem KeskinOmer Kalayci
Oct 13, 2000·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·H KangJ W Kim
Feb 7, 2001·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·J L HuangK H Hsieh
Aug 1, 1997·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·C MooreR U Sorensen
Aug 2, 2003·International Immunopharmacology·Yoshifumi TaniguchiMasashi Kurimoto
Jul 17, 2009·The British Journal of Nutrition·P C CalderJ Zhao
Sep 15, 1999·Allergy·M S de Bruin-WellerC A Bruijnzeel-Koomen
Nov 13, 2001·Allergy·K BreuerT Werfel
Nov 29, 2001·British Journal of Pharmacology·A Ikegami-KuzuharaT Saito
May 11, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C MacaubasP G Holt
Sep 1, 1999·The British Journal of Dermatology·M GrassbergerG Zenke
Jun 10, 2000·The British Journal of Dermatology·R C KiekensC A Bruijnzeel-Koomen
May 22, 2001·The British Journal of Dermatology·C C BanfieldJ I Harper
Jul 17, 2001·The British Journal of Dermatology·C GutgesellC Neumann
Sep 1, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C MacaubasP G Holt
May 8, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T J NuttallP B Hill
May 8, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K Matsui, A Nishikawa
May 8, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J M Smart, A S Kemp
Aug 10, 2000·Clinical and Experimental Immunology·N KatohH Yasuno
May 1, 2001·International Journal of Dermatology·G G Russo, C Mullen
Nov 13, 2001·International Journal of Dermatology·L LugovićJ Jakić-Razumović
Mar 27, 2002·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·S HayashiyaY Taura

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