PMID: 278Jul 1, 1975

Biphasic (ulcer-forming and ulcer-preventing) effect of adrenaline in rats

Nihon yakurigaku zasshi. Folia pharmacologica Japonica
T DozakiS Mizukami

Abstract

Adrenaline-induced gastric ulceration was studied in rats. Adrenaline in high doses caused gastric ulcer, which was completely blocked by pretreatment with alpha-blockers (phenoxybenzamine, dibenamine), but not by pretreatment with propranolol or atropine, nor by vagotomy, hypophysectomy or adrenalectomy. After successive administration of adrenaline, once daily for 7 days, however, no gastric ulcer was observed. Recovery from the ulcerogenic action of adrenaline was seen after 4 weeks withdrawal. Pretreatment with a small dose of adrenaline inhibited the ulcerogenic action of a high dose of adrenaline. Pretreatment with reserpine, pyrogallol or iproniazid inhibited the action of adrenaline. It is concluded that adrenaline has a biphasic effect on gastric ulceration, the ulcerogenic action is due to its alpha-action and antiulcerogenic effect is due to development of tachyphylaxis.

Related Concepts

Adrenalectomy
Adrenergic alpha-Antagonists
Adrenergic beta-Antagonists
Metazoa
Atropine Sulfate Anhydrous
Catecholamines
Dose-Response Relationship, Drug
Epinephrine Acetate
Antihistamines, Classical
Hypophysectomy

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