Bipolar disorder and chromosome 18: an analysis of multiple data sets

Genetic Epidemiology
J A Badner, L R Goldin

Abstract

There have been conflicting reports of linkage between bipolar disorder and chromosome 18. We have analyzed five separate data sets using the two-point affected sib-pair method and family based association methods. We have found evidence of linkage in multiple data sets and differences in maternal and paternal allele sharing. Suggestive, though nonsignificant, evidence of linkage disequilibrium of two tightly linked markers has also been demonstrated in multiple data sets.

References

May 1, 1984·American Journal of Medical Genetics·B K Suarez, P Van Eerdewegh
Jun 21, 1994·Proceedings of the National Academy of Sciences of the United States of America·W H BerrettiniE S Gershon
Apr 9, 1996·American Journal of Medical Genetics·E S GershonW H Berrettini

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