Bipolar Mood State Reflected in Functional Connectivity of the Hate Circuit: A Resting-State Functional Magnetic Resonance Imaging Study

Frontiers in Psychiatry
Zebin FanHaojuan Tao

Abstract

Previous studies suggested bipolar disorder caused an aberrant alteration in the insular, putamen, and left superior frontal gyrus, which are the main components of the hate circuit. However, the relationship between the hate circuit and the pathophysiologic substrate underlying different phases of bipolar disorder remain unclear. In this study, we aimed to identify group differences of resting-state functional connectivity within the hate circuit in healthy controls (HCs) and bipolar patients in different mood states. Resting-state functional magnetic resonance imaging of the brain were acquired from 54 HCs and 81 patients with bipolar disorder including 20 with bipolar mania (BM), 35 with bipolar depression (BD), and 26 with bipolar euthymia (BE). We selected bilateral insula (L.INS and R.INS), bilateral putamen (L.PUT and R.PUT), and left superior frontal gyrus (L.SFGd) as seed regions, and conducted the seed-based functional connectivity analysis to identify group differences of connectivity strength within the hate circuit. Spearman correlations were performed to evaluate the relationship between the hate circuit and manic/depressive symptoms. Significant group differences of connectivity strength within the hate circuit w...Continue Reading

References

Nov 1, 1978·The British Journal of Psychiatry : the Journal of Mental Science·R C YoungD A Meyer
Apr 24, 1997·Nature·W C DrevetsM E Raichle
Mar 14, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P A BandettiniJ S Hyde
Oct 25, 2002·Journal of Anxiety Disorders·Richard J McNally
Aug 30, 2003·Biological Psychiatry·Mary L PhillipsRichard Lane
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON
Sep 21, 2006·Brain : a Journal of Neurology·Foucaud du BoisgueheneucBruno Dubois
Jun 2, 2007·The British Journal of Psychiatry : the Journal of Mental Science·Bunmi O Olatunji, Dean McKay
Oct 30, 2008·PloS One·Semir Zeki, John Paul Romaya
Dec 20, 2008·Nature Reviews. Neuroscience·A D Bud Craig
Jan 1, 2009·International Review of Psychiatry·Michael A CerulloStephen M Strakowski
Apr 22, 2010·Frontiers in Systems Neuroscience·David M ColeChristian F Beckmann
Nov 6, 2010·Psychiatry Research·Astrid Van der SchotMatthijs Vink
Oct 5, 2011·Molecular Psychiatry·H TaoJ Feng
Jan 11, 2012·Progress in Brain Research·Rudolf Nieuwenhuys
May 29, 2012·Bipolar Disorders·Stephen M StrakowskiJennifer D Townsend
Oct 2, 2013·Indian Journal of Psychiatry·Maurizio PompiliPaolo Girardi
Sep 15, 2014·Psychiatry Research·Li-Rong TangChuan-Yue Wang
Dec 17, 2014·The British Journal of Psychiatry : the Journal of Mental Science·Edith Pomarol-ClotetRaymond Salvador
Apr 8, 2015·Journal of Affective Disorders·Wenbin GuoJingping Zhao
Sep 22, 2015·Lancet·Iria GrandeEduard Vieta
Apr 14, 2016·Proceedings of the National Academy of Sciences of the United States of America·Matteo MartinoGeorg Northoff
Apr 15, 2016·Neuroinformatics·Chao-Gan YanYu-Feng Zang
May 14, 2016·Journal of Affective Disorders·Roscoe O BradyMatcheri Keshavan
Oct 17, 2016·Journal of Affective Disorders·Roscoe O BradyDost Öngür
Mar 30, 2017·The Neuroradiology Journal·K A SmithaChandrasekharan Kesavadas
Apr 18, 2017·Journal of Affective Disorders·Roscoe O BradyDost Öngür

❮ Previous
Next ❯

Software Mentioned

Statistic Package for Social Science ( SPSS )
DPABI

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

Related Papers

Family Process
Elaine B Pinderhughes
Narrative Inquiry in Bioethics
Claire Yar
Nursing Standard
Stephen Wright
Integrative Medicine
Bill Benda
© 2021 Meta ULC. All rights reserved