Bipolar stimulation of a three-dimensional bidomain incorporating rotational anisotropy

IEEE Transactions on Bio-medical Engineering
A L Muzikant, C S Henriquez

Abstract

A bidomain model of cardiac tissue was used to examine the effect of transmural fiber rotation during bipolar stimulation in three-dimensional (3-D) myocardium. A 3-D tissue block with unequal anisotropy and two types of fiber rotation (none and moderate) was stimulated along and across fibers via bipolar electrodes on the epicardial surface, and the resulting steady-state interstitial (phi e) and transmembrane (Vm) potentials were computed. Results demonstrate that the presence of rotated fibers does not change the amount of tissue polarized by the point surface stimuli, but does cause changes in the orientation of phi e and Vm in the depth of the tissue, away from the epicardium. Further analysis revealed a relationship between the Laplacian of phi e, regions of virtual electrodes, and fiber orientation that was dependent upon adequacy of spatial sampling and the interstitial anisotropy. These findings help to understand the role of fiber architecture during extracellular stimulation of cardiac muscle.

References

May 1, 1989·Biophysical Journal·N G SepulvedaJ P Wikswo
Jul 1, 1987·IEEE Transactions on Bio-medical Engineering·W KrassowskaR E Ideker
Jan 1, 1986·Annals of Biomedical Engineering·R Plonsey, R C Barr
Nov 1, 1970·The Journal of Physiology·S Weidmann
Sep 1, 1995·Pacing and Clinical Electrophysiology : PACE·W Krassowska
Oct 1, 1994·Pacing and Clinical Electrophysiology : PACE·M Neunlist, L Tung
Mar 1, 1994·Biophysical Journal·S B KnisleyR E Ideker
Feb 1, 1994·IEEE Transactions on Bio-medical Engineering·W Krassowska, J C Neu
Mar 1, 1994·IEEE Transactions on Bio-medical Engineering·B J Roth, J P Wikswo
Mar 1, 1994·Journal of Cardiovascular Electrophysiology·N G Sepulveda, J P Wikswo
Dec 1, 1996·IEEE Transactions on Bio-medical Engineering·N Trayanova
Jan 1, 1963·Circulation Research·S RUSH McFEER

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Citations

Jun 29, 2006·Annals of Biomedical Engineering·R Sadleir, C Henriquez
Dec 7, 2002·Computer Methods in Biomechanics and Biomedical Engineering·J SundnesA Tveito
Apr 22, 2009·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·S LingeA Tveito
Feb 12, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Bruno TaccardiPhilip R Ershler
Aug 18, 2004·IEEE Transactions on Bio-medical Engineering·Marie-Claude TrudelL Joshua Leon
Dec 13, 2006·IEEE Transactions on Bio-medical Engineering·Mark PotseRamesh M Gulrajani
Aug 16, 2000·IEEE Transactions on Bio-medical Engineering·D PorrasA E Pollard
May 7, 1999·IEEE Transactions on Bio-medical Engineering·D C Latimer, B J Roth
Aug 31, 1999·Biophysical Journal·S B KnisleyF Aguel
Jul 5, 2005·Circulation Research·Christopher J HyattArkady M Pertsov
Aug 24, 2002·Circulation Research·Darren A HooksPeter J Hunter
Apr 6, 2002·Circulation Research·Vladimir G Fast, Eric R Cheek
Mar 10, 2000·American Journal of Physiology. Heart and Circulatory Physiology·V G FastR E Ideker
Jul 3, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Yi JiangEdward W Hsu
Oct 2, 2017·Chaos·Suran K GalappaththigeBradley J Roth
Apr 17, 2020·Frontiers in Physiology·Archontis Giannakidis, Grant T Gullberg
Aug 17, 2005·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Joseph V TranquilloCraig S Henriquez

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