Birch allergy and oral allergy syndrome: The practical relevance of serum immunoglobulin E to Bet v 1

Allergy and Asthma Proceedings
G CiprandiMichele Mussap

Abstract

Birch allergy (BA) may frequently be associated with fruit-vegetables oral allergy syndrome (OAS). Bet v 1 is the major birch allergen. Previously, it was reported that serum-specific immunoglobulin E (IgE) level could differentiate allergy from sensitization. Thus, this study aimed to investigate the practical role of Bet v 1 IgE. A total of 245 subjects (128 women, 117 men; mean age, 41 years) with suspected allergic rhinitis and sensitization to Bet v 1 were evaluated. Serum IgE to Bet v 1 was assessed by using immuno-enzymatic. BA and OAS were diagnosed according to validated criteria. Symptom severity perception was measured by the visual analog scale. A total of 158 patients (64.5%) had BA. Patients with BA had higher serum Bet v 1 IgE levels than subjects who were sensitized (p < 0.0001). A cutoff value of 8.94 kUA/L predicted BA (area under the curve, 0.76; odds ratio, 6.18). Fifty-three patients with BA (33.5%) had OAS. Patients positive for OAS had higher Bet v 1 levels (p < 0.0001) and more-severe symptoms (p < 0.0001) than patients with BA and negative for OAS. A cutoff value of 17.4 kUA/L predicted OAS (area under the curve, 0.59; odds ratio, 3.19). The present study demonstrated that serum IgE levels to Bet v 1 co...Continue Reading

Citations

Sep 7, 2016·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Aneta WagnerWaldemar Wagner
Oct 11, 2016·Allergologia et immunopathologia·M A ToscaG Ciprandi
Jan 14, 2017·Scientific Reports·Maria J RodriguezCristobalina Mayorga
Aug 9, 2017·International Archives of Allergy and Immunology·Enrico ScalaRiccardo Asero
Jan 18, 2018·American Journal of Rhinology & Allergy·Nuray Bayar Muluk, Cemal Cingi
Apr 7, 2017·Allergy & Rhinology·Angelo G CorsicoGiorgio Ciprandi
Feb 9, 2019·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Francesca CiprianiUNKNOWN Italian Pediatric Allergy Network (I-PAN)
Mar 5, 2019·Allergy·T BiedermannE Valovirta
Feb 14, 2018·International Forum of Allergy & Rhinology·Sarah K WiseMark Zacharek
Dec 18, 2020·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Christine LoraudJocelyne Just
Jun 16, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yukinori KatoShigeharu Fujieda

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