Birefringence of the secretory-stage enamel organic extracellular matrix from rats submitted to successive injections of bisphosphonates

Connective Tissue Research
A R do Espirito SantoSérgio Roberto Peres Line

Abstract

The aim of the present study was to assess birefringence of the secretory-stage enamel organic extracellular matrix (ECM) and mechanical properties of mature enamel from rats treated with bisphosphonates. Longitudinal sections were obtained from upper incisors of rats that had been submitted to injections of bisodic etidronate (8 mg/Kg/day), sodium alendronate (30 microg/Kg/day), or sodium chloride as control (8 mg/Kg/day) for 42 days. Sections were immersed in 80% glycerin for 30 min and optical retardation of birefringence brightness in the secretory-stage enamel organic ECM was determined in nanometers. Etidronate-treated rats exhibited extensive morphological changes in the secretory-stage enamel organic ECM inclusive nonbirefringent conspicuous incremental lines, but presented optical retardation values similar to those showed by control rats (p > 0.05). Birefringence of secretory enamel organic ECM from etidronate rats presented an irregular aspect. Alendronate-treated rats did not show morphological alterations in the secretory-stage enamel organic ECM, however, they presented significant reduction in optical retardation of birefringence brightness when compared with control and etidronate rats (p < 0.01). Alendronate an...Continue Reading

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Citations

Jul 31, 2013·Journal of Periodontology·Daniel Fernando Pereira VasconcelosPedro Duarte Novaes
Feb 20, 2016·Environmental Toxicology and Pharmacology·Ana Prates SoaresAlexandre Ribeiro do Espírito Santo
Jun 19, 2012·The British Journal of Oral & Maxillofacial Surgery·Toshinori IwaiIwai Tohnai
May 24, 2016·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Ana P SoaresAlexandre R do Espírito Santo
Nov 12, 2015·Clinical Oral Investigations·Paulo Nelson-FilhoRegina Guenka Palma-Dibb

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