Recent studies have revealed increased morbidity and mortality rates in term neonates without birth defects who were delivered before 39 weeks of completed gestation. We sought to determine if a similar association exists between gestational age at delivery and adverse outcomes in neonates with critical congenital heart disease, with particular interest in those born at 37 to 38 weeks' gestation. We studied 971 consecutive neonates who had critical congenital heart disease and a known gestational age and were admitted to our cardiac ICU from 2002 through 2008. Gestational age was stratified into 5 groups: >41, 39 to 40, 37 to 38, 34 to 36, and <34 completed weeks. Multivariate logistic regression analyses were used to evaluate mortality and a composite morbidity variable. Multivariate Poisson regression was used to evaluate duration of ventilation, intensive care, and hospitalization. Compared with the referent group of neonates who were delivered at 39 to 40 completed weeks' gestation, neonates born at 37 to 38 weeks had increased mortality (6.9% vs 2.6%; adjusted P = .049) and morbidity (49.7% vs 39.7%; adjusted P = .02) rates and tended to require a longer duration of mechanical ventilation (adjusted P = .05). Patients born ...Continue Reading
Outcomes and risk factors for mortality in premature neonates with critical congenital heart disease
The impact of gestational age on resource utilization after open heart surgery for congenital cardiac disease from birth to 1 year of age
Regulatory volume decrease in Ehrlich ascites tumor cells is not mediated by a rise in intracellular calcium
Early developmental outcome in children with hypoplastic left heart syndrome and related anomalies: the single ventricle reconstruction trial
Prenatal polychlorinated biphenyl exposure is associated with decreased gestational length but not birth weight: archived samples from the Child Health and Development Studies pregnancy cohort
The use of reconstructive surgery to improve quality of life and survival in prenatal hypoplastic left heart syndrome
Interstage mortality after the Norwood procedure: Results of the multicenter Single Ventricle Reconstruction trial
Risk factors for hospital morbidity and mortality after the Norwood procedure: A report from the Pediatric Heart Network Single Ventricle Reconstruction trial
Younger gestational age is associated with worse neurodevelopmental outcomes after cardiac surgery in infancy
Mortality as an outcome measure following cardiac surgery for congenital heart disease in the current era
Catheterization-based intervention in low birth weight infants less than 2.5 kg with acute and long-term outcome
Impact of change in delivery practice on neonatal and maternal outcomes in cases of significant congenital heart disease
Contemporary Outcomes and Factors Associated With Mortality After a Fetal or Neonatal Diagnosis of Ebstein Anomaly and Tricuspid Valve Disease
Outcomes of cardiac surgery in patients weighing <2.5 kg: affect of patient-dependent and -independent variables
Prenatal diagnosis of transposition of the great arteries over a 20-year period: improved but imperfect
Alternative strategies in newborns and infants with major co-morbidities to improve congenital heart surgery outcomes at an emerging programme
Congenital heart disease infant death rates decrease as gestational age advances from 34 to 40 weeks
Impact of mode of delivery on markers of perinatal hemodynamics in infants with hypoplastic left heart syndrome
Impact of prenatal diagnosis in survivors of initial palliation of single ventricle heart disease: analysis of the national pediatric cardiology quality improvement collaborative database
Patterns and Associated Factors of Caesarean Delivery Intention among Expectant Mothers in China: Implications from the Implementation of China's New National Two-Child Policy
Early-Term Birth in Single-Ventricle Congenital Heart Disease After the Fontan Procedure: Neurodevelopmental and Psychiatric Outcomes
Cardiovascular profile score as a predictor of acute intrapartum non-reassuring fetal status in infants with congenital heart defects
Late-Term Gestation Is Associated With Improved Survival in Neonates With Congenital Heart Disease Following Postoperative Extracorporeal Life Support
Does Birth at Early-Term Gestation Increase Mortality for Neonates on Extracorporeal Life Support After Cardiac Surgery?
Fetal echocardiography for planning perinatal and delivery room care of neonates with congenital heart disease
The impact of the maternal-foetal environment on outcomes of surgery for congenital heart disease in neonates
Gestational age at birth and outcomes after neonatal cardiac surgery: an analysis of the Society of Thoracic Surgeons Congenital Heart Surgery Database
Best on time, not a little early: gestational age and outcomes for neonates with congenital heart disease
Neurodevelopmental outcomes in children with congenital heart disease: evaluation and management: a scientific statement from the American Heart Association
Diagnosis and treatment of fetal cardiac disease: a scientific statement from the American Heart Association
Preoperative Stabilization of Infants With Hypoplastic Left Heart Syndrome Before Stage I Palliation
Adverse perinatal outcome and placental abnormalities in pregnancies with major fetal congenital heart defects: A retrospective case-control study
Hemoglobin Level at Stage 1 Discharge has No Impact on Inter-stage Growth and Stability in Single Ventricle Infants
Preterm Birth of Infants Prenatally Diagnosed with Congenital Heart Disease, Characteristics, Associations, and Outcomes
Impact of preterm birth on infant mortality for newborns with congenital heart defects: The EPICARD population-based cohort study
Neonatal cardiac surgery in low and middle-income countries: importance of foetal maturation on postoperative outcomes
Cognitive function in toddlers with congenital heart disease: The impact of a stimulating home environment.
Effect of In Utero Non-Steroidal Anti-Inflammatory Drug Therapy for Severe Ebstein Anomaly or Tricuspid Valve Dysplasia (NSAID Therapy for Fetal Ebstein anomaly).
Outcomes of Preterm Infants With Congenital Heart Defects After Early Surgery: Defining Risk Factors at Different Time Points During Hospitalization.
Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.