Birth-date dependent alignment of GABAergic neurons occurs in a different pattern from that of non-GABAergic neurons in the developing mouse visual cortex

Neuroscience Research
Masato YozuKazunori Nakajima

Abstract

In the developing mouse cerebral cortex, gamma-aminobutyric acid (GABA)ergic neurons and non-GABAergic neurons arise in distinct places and migrate into the cortical plate (CP) via different pathways. Although the "inside-out" alignment of projection neurons in the cortex has been thoroughly analyzed, the pattern of interneuron alignment is not well understood. Herein, we show that in the postnatal day (P) 9.5 mouse visual cortex, GABAergic neurons born on embryonic day (E) 12.5 were distributed around two peak locations, mainly around layer V and also around layer II/III, while non-GABAergic neurons born on E12.5 were distributed around only one peak in layer VI. Both cell populations born on E15.5 exhibited only one common peak distribution in layer II/III. The two peak locations of GABAergic neurons born on E12.5 still existed at P30. When the subtypes of GABAergic neurons were analyzed, calretinin-positive cells born on E12.5 were distributed in the cortex around one peak location near layer II/III, whereas somatostatin-positive E12.5 cells were distributed in the cortex around one peak location near layer V. These results suggest that the alignment of interneurons is regulated differently according to subtypes and from tha...Continue Reading

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Citations

Dec 20, 2008·Proceedings of the National Academy of Sciences of the United States of America·Dragos IntaHannah Monyer
Apr 14, 2009·Cerebral Cortex·Vitor H SousaGord Fishell
Aug 14, 2013·Annual Review of Cell and Developmental Biology·Irina EvsyukovaE S Anton
May 11, 2012·Neuro-Signals·Clare FauxJoanne M Britto
Feb 5, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Goichi MiyoshiGord Fishell
Apr 12, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Setsuko SaharaCharles F Stevens
Jan 7, 2014·Trends in Cell Biology·Jiami Guo, E S Anton
Jan 22, 2011·Neurochemical Research·Takao HondaKazunori Nakajima
Nov 20, 2015·Neurotoxicology·John F TrentiniSharon L Juliano
May 12, 2009·Neuroscience Research·Haruyasu Watanabe, Fujio Murakami
Jun 26, 2007·Neurochemistry International·Kazunori Nakajima
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Dec 15, 2010·Developmental Neurobiology·Jelle Welagen, Stewart Anderson
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Aug 3, 2006·Nature Reviews. Neuroscience·Carl P Wonders, Stewart A Anderson

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