Birth prevalence of congenital heart disease in China, 1980-2019: a systematic review and meta-analysis of 617 studies

European Journal of Epidemiology
Lijuan ZhaoJiabi Qin

Abstract

To assess the birth prevalence and spatial distribution of congenital heart disease (CHD) in China by conducting a complete overview and using spatial epidemiological methods. Unrestricted searches were conducted on seven electronic databases, with an end-date parameter of May 2019. Data on the birth prevalence of CHD and its subtypes were collected and combined using either the random-effect model or fixed-effect model. Subgroup sensitivity analyses were performed to explore potential heterogeneity moderators. The three-dimensional trend analysis and a visualization of CHD birth prevalence among different provinces were performed to describe the spatial distribution characteristics. Total 617 studies involving 76,961,354 births and 201,934 CHD individuals were included. Overall, total CHD birth prevalence increased continuously over time, from 0.201‰ in 1980-1984 to 4.905‰ in 2015-2019. The study on the high-income provinces, population-based monitoring model, male births, and urban regions reported a significantly higher prevalence of total CHD compared with upper-middle-income provinces, hospital-based monitoring model, female births, and rural regions, respectively. National CHD birth prevalence increased gradually from wes...Continue Reading

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Citations

Nov 30, 2020·The Science of the Total Environment·Qi ZhangJiyu Cao
May 18, 2021·Journal of the American Heart Association·Xie WuFuxia Yan
Jun 27, 2021·Nature Reviews. Cardiology·Sean CoffeyBernard D Prendergast
Sep 4, 2021·Environmental Science and Pollution Research International·Xiaolin YuYingxian Zhu

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