Birth prevalence of non-syndromic orofacial clefts in Saudi Arabia and the effects of parental consanguinity

Saudi Medical Journal
Heba Jafar SabbaghPeter A Mossey

Abstract

To describe the characteristics and prevalence of non-syndromic orofacial clefting (NSOFC) and assess the effects of parental consanguinity on NSOFC phenotypes in the 3 main cities of Saudi Arabia. All infants (114,035) born at 3 referral centers in Riyadh, and 6 hospitals in Jeddah and Madinah between January 2010 and December 2011 were screened. The NSOFC cases (n=133) were identified and data was collected through clinical examination and records, and information on consanguinity through parent interviews. The diagnosis was confirmed by reviewing medical records and contacting the infants' pediatricians. Control infants (n=233) matched for gender and born in the same hospitals during the same period, were selected. The prevalence of NSOFC was 1.07/1000 births in Riyadh, and 1.17/1000 births overall; cleft lip (CL) was 0.47/1000 births, cleft lip and palate (CLP) was 0.42/1000 births, and cleft palate (CP) was 0.28/1000 births. Cleft palate was significantly associated with consanguinity (p=0.047, odds ratio: 2.5, 95% confidence interval: 1 to 6.46), particularly for first cousin marriages. The birth prevalence of NSOFC in Riyadh alone, and in the 3 main cities of Saudi Arabia were marginally lower than the mean global preval...Continue Reading

Citations

Apr 18, 2019·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Omar B SaeedJohn A van Aalst
Jun 11, 2020·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Bandar AlyamiSaeed Alharieth
Aug 11, 2018·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Meow-Keong ThongJaffar Ali
May 1, 2018·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Wasmiya A AlhayyanFawzi M AlQatami
Aug 15, 2020·Frontiers in Cell and Developmental Biology·Mohammad Khursheed Alam, Ahmed Ali Alfawzan
Oct 31, 2020·Genetic Testing and Molecular Biomarkers·Hadiah Bassam Al MahdiHeba Jafar Sabbagh
Mar 12, 2021·Global Medical Genetics·Mahamad Irfanulla KhanNarasimha Murthy Srinath
Mar 12, 2021·The Journal of Craniofacial Surgery·Arezoo JahanbinAhmad Ehsan Niazi
May 26, 2021·Journal of Stomatology, Oral and Maxillofacial Surgery·Nader SalariMasoud Mohammadi
May 29, 2021·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Diluma Kariyawasam, Shayesteh Jahanfar
Jul 1, 2021·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Hanaa AllafHeba Sabbagh

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Software Mentioned

SPSS
Open Epidemiologic Statistics for ( OpenEpi )
Statistical Package for Social Sciences

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