Abstract
The birth prevalence of orofacial clefts (OFCs) has been widely studied, but results are considerable varied, and epidemiological studies in southern China are few in numbers. To address this gap, we carried out a register-based study to estimate the birth prevalence of OFCs in Bao'an district, Shenzhen, China. Data of perinatal infants born between 2003 and 2017 were extracted from Shenzhen Maternal and Child Health Management System. The overall OFCs birth prevalence with 95% confidence interval (CI) as well as subgroup analysis based on selected demographic factors was conducted. Cochran-Armitage trend tests were applied to evaluate the time trend by 5-year intervals. The overall birth prevalence of OFCs, cleft lip with or without cleft palate (CL/P) and cleft palate only (CPO) was 1.30 (95% CI 1.21-1.39), 1.00 (95% CI 0.92-1.08), and 0.30 (95% CI 0.25-0.34) per 1,000 births, respectively. An overall declining tendency was observed in the OFCs (from 1.83 to 1.04 per 1,000 births), specifically CL/P (from 1.53 to 0.69 per 1,000 births) birth prevalence over 5-year intervals, with statistical significance (p < 0.01). Subgroup analysis revealed that the CL/P and CPO birth prevalence was differed by infant gender, household regi...Continue Reading
References
Mar 4, 2000·Plastic and Reconstructive Surgery·K C ChungS R Buchman
Jan 28, 2004·Birth Defects Research. Part A, Clinical and Molecular Teratology·Monica RittlerEduardo E Castilla
Nov 2, 2004·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·F Al Omari, I K Al-Omari
Mar 22, 2005·American Journal of Medical Genetics. Part a·Syed Shahrukh HashmiJacqueline T Hecht
Jun 11, 2005·European Journal of Orthodontics·Orlagh HuntChris Johnston
May 10, 2006·Journal of Applied Genetics·Margot I Van AllenSoo-Hong Uh
Jun 13, 2006·Journal of Occupational and Environmental Medicine·Jean D BrenderKaren Moody
Jul 27, 2007·Orthodontics & Craniofacial Research·Peter Mossey
Sep 18, 2008·American Journal of Medical Genetics. Part a·Zhiwen LiZhu Li
Sep 15, 2009·Lancet·Peter A MosseyWilliam C Shaw
Dec 17, 2009·Annals of Epidemiology·Lynne C MesserPeter H Langlois
Feb 19, 2011·Nature Reviews. Genetics·Michael J DixonJeffrey C Murray
May 7, 2011·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Fedik RahimovJeffrey C Murray
Sep 3, 2011·Trends in Molecular Medicine·Elisabeth MangoldMarkus M Nöthen
Oct 25, 2011·Journal of Dentistry·Ana Paula Corrêa de Queiroz HerkrathMario Vianna Vettore
Mar 1, 2012·Birth Defects Research. Part A, Clinical and Molecular Teratology·Hao T DuongUNKNOWN National Birth Defects Prevention Study
Mar 15, 2012·Epidemiology·Song LiRobert J Berry
May 15, 2013·Birth Defects Research. Part A, Clinical and Molecular Teratology·Azeez ButaliPeter A Mossey
Oct 15, 2013·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Elizabeth J Leslie, Mary L Marazita
Apr 3, 2014·Annals of Plastic Surgery·Ahmad N SaadAmanda Gosman
May 16, 2014·Oral Diseases·Rf FigueiredoA S Damazo
Jul 1, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Mei YangYukai Du
Oct 25, 2014·Journal of Public Health Research·Vitaly A PostoevArild Vaktskjold
Feb 26, 2015·American Journal of Medical Genetics. Part a·Adrian M MichalskiCharlotte M Druschel
Oct 19, 2016·Lancet·Yi Zeng, Therese Hesketh
Jun 22, 2017·Birth Defects Research·Mengying WangTerri H Beaty