Birth weight and polycystic ovary syndrome in adult life: is there a causal link?

PloS One
Stavroula A PaschouAndromachi Vryonidou

Abstract

Several studies have demonstrated associations of birth weight with metabolic and reproductive abnormalities in adults. The aim of this study was to investigate the birth weight in women with PCOS and its correlation with clinical and biochemical characteristics of the syndrome. We studied 288 women with PCOS according to the NIH criteria and 166 women with normal cycle and without clinical hyperandrogenism. Birth weight and anthropometric characteristics were recorded, and levels of serum androgens, SHBG, insulin and fasting glucose were measured. Birth weight data were available for 243/288 women with PCOS and age- and BMI-matched 101/166 controls. No differences were found (p> 0.05) in birth weight among women with PCOS and normal controls. Birth weight of PCOS women was negatively correlated with DHEAS levels (p = 0.031, r = -0.143) and positively correlated with waist circumference (p <0.001, r = 0.297) and body mass index (BMI) (p = 0.040, r = 0.132). Birth weight of controls was negatively correlated with SHBG levels (p = 0.021, r = -0.234). Women from both groups were further divided in 6 categories according to birth weight (A. <2.500 gr, B. 2.501-3.000 gr, C. 3.001-3.500 gr, D. 3.501-4.000 gr, E. 4.001-4.500 gr, F. > ...Continue Reading

References

Feb 1, 1991·Fertility and Sterility·S McCluskeyH Jacobs
Aug 1, 1981·American Journal of Obstetrics and Gynecology·R HatchD Tredway
Jan 27, 1999·The Journal of Clinical Endocrinology and Metabolism·G GennarelliC Berne
Nov 24, 1999·The Journal of Clinical Endocrinology and Metabolism·D JaquetC Levy-Marchal
Jul 2, 2003·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·J LaitinenM R Järvelin
Nov 27, 2004·Biology of the Neonate·Peter D GluckmanCatherine S Pinal
Apr 2, 2005·Human Reproduction·Teresa Sir-PetermannFernando Cassorla
Feb 14, 2006·Cell·William Rosner
Dec 14, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Shelley S TworogerSusan E Hankinson
Jan 12, 2007·American Journal of Epidemiology·Thomas HarderAndreas Plagemann
Aug 19, 2007·Trends in Endocrinology and Metabolism : TEM·Héctor F Escobar-Morreale, José L San Millán
May 9, 2008·The Journal of Clinical Endocrinology and Metabolism·Ricardo Azziz
Jun 17, 2008·Metabolism: Clinical and Experimental·Caterina PandolfiFelice Francavilla
Mar 26, 2009·The Journal of Clinical Endocrinology and Metabolism·Johanna PuurunenJuha S Tapanainen
Aug 7, 2009·The New England Journal of Medicine·Eric L DingSimin Liu
Sep 8, 2009·Molecular and Cellular Endocrinology·Nectaria Xita, Agathocles Tsatsoulis
Oct 8, 2009·The Journal of Clinical Endocrinology and Metabolism·Francis de Zegher, Lourdes Ibáñez
Sep 16, 2010·Annals of the New York Academy of Sciences·Nektaria Xita, Agathocles Tsatsoulis
Dec 24, 2010·The Journal of Clinical Endocrinology and Metabolism·Marios C MarkopoulosGeorge Mastorakos
Mar 23, 2011·Current Diabetes Reports·Jennifer Villa, Richard E Pratley
Oct 15, 2011·BMJ : British Medical Journal·Nathalie RoosOlof Stephansson
Dec 14, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S CnattingiusF Granath
Oct 16, 2012·Endocrine Reviews·Evanthia Diamanti-Kandarakis, Andrea Dunaif
Jun 12, 2013·Clinical Obstetrics and Gynecology·Michael G Ross, Mina Desai
May 23, 2014·European Journal of Endocrinology·Gerard ConwayUNKNOWN ESE PCOS Special Interest Group

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Citations

Jun 3, 2015·European Journal of Endocrinology·Andromachi VryonidouDimitrios G Goulis
May 26, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Sheda SadrzadehCornelis B Lambalk
Jun 14, 2018·BJOG : an International Journal of Obstetrics and Gynaecology·H ValgeirsdottirA-K Wikström
Sep 6, 2020·Current Opinion in Pediatrics·Robert L Rosenfield
Mar 10, 2017·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·M Stracquadanio, L Ciotta
Aug 19, 2017·Human Reproduction Open·S SadrzadehC B Lambalk
Jun 25, 2020·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Stavroula A PaschouChristina Kanaka-Gantenbein
Jan 21, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Stavroula A PaschouChristina Kanaka-Gantenbein

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Software Mentioned

Statistical Package for Social Sciences ( SPSS

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