Birth weight deviation and early postnatal growth are related to optic nerve morphology at school age in children born preterm

Pediatric Research
Margareta H WikstrandAnn Hellström

Abstract

The aim of this study was to evaluate the influence of early and later postnatal growth variables on optic disc morphology in children (n = 53) born at gestational age <32 wk. On fundus photographs taken at a median age of 5.4 y, the optic discs were evaluated using digital image analysis and compared with those of a control group (n = 203). The results were analyzed in relation to gestational age, birth weight (BW) SD score (SDS), IGF-1 weight at postmenstrual age 32 wk (SDS), and weight, length, and head circumference (SDS) at follow-up. The preterm children's optic disc and neuronal rim areas were smaller than in the control group. Low BW (SDS) and weight at wk 32 (SDS) were associated with larger area of the optic cup and reduced neuronal rim area. Preterm children with known brain lesions (n = 6) had significantly larger cups than preterm children without known brain lesions. The association found between both low BW and poor early growth and later reduced neuronal tissue of the optic nerve indicate that early weight gain is important for neural development in preterm children.

References

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Citations

Oct 26, 2011·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Julie F McClellandKathryn J Saunders
Oct 29, 2013·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Michael J AllinghamMays A El-Dairi
Aug 20, 2016·Journal of the Neurological Sciences·Deepta GhateSachin Kedar
May 1, 2020·Acta Ophthalmologica·Alexandra LindMarita Andersson Grönlund
Apr 9, 2013·European Journal of Ophthalmology·Sophie VanhaesebrouckFrancis De Zegher

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