Birthweight, body-mass index in middle age, and incident coronary heart disease

Lancet
S FrankelG D Smith

Abstract

Several studies have shown a relation between fetal development, as shown by birthweight, and later coronary heart disease. This study investigated whether this relation is predominantly the consequence of early life exposures, or can best be explained in terms of an interaction between influences in early life and in adulthood. This prospective study in Caerphilly, South Wales, included 1258 men, aged 45-59 at initial screening, who were able to provide birthweight data. These men are from an initial cohort of 2512 men, from whom information has been obtained in a series of examinations since 1979 on health-related behaviours, incidence of coronary heart disease, and risk factors. The main outcome measure was fatal and non-fatal coronary heart disease during 10 years of follow-up. Higher birthweight was related to lower risk of coronary heart disease during the follow-up period: coronary heart disease occurred in 46 (11.6%) men in the lowest birthweight tertile, 44 (12.0%) of those in the middle tertile, and 38 (9.1%) of those in the highest tertile (p = 0.03). Stratification of the cohort by body-mass index (BMI) revealed a significant interaction such that the inverse association between birthweight and risk of coronary hear...Continue Reading

References

Aug 12, 1976·The New England Journal of Medicine·G P RavelliM W Susser
May 14, 1994·Lancet·I Emanuel

❮ Previous
Next ❯

Citations

Sep 28, 2010·European Journal of Epidemiology·J J Miranda Geelhoed, Vincent W V Jaddoe
Feb 6, 2013·Environmental Health and Preventive Medicine·Hidekuni Inadera
Jul 14, 2012·Indian Pediatrics·Sudha ChaudhariMehmood Sayyad
Dec 10, 2013·Best Practice & Research. Clinical Rheumatology·Kate M DunnJ David Cassidy
Nov 20, 2003·Nutrition·Undurti N Das
Jul 13, 2013·Revue D'épidémiologie Et De Santé Publique·M-A Charles
Mar 30, 2004·Social Science & Medicine·Tiina Pensola, Pekka Martikainen
Jun 24, 2004·Social Science & Medicine·Sarah Burgard
Mar 29, 2000·Theriogenology·D J Barker
Jun 7, 2003·Social Science & Medicine·Bitte Modin
Jun 11, 1998·European Journal of Obstetrics, Gynecology, and Reproductive Biology·K M Godfrey
Oct 9, 2002·Trends in Endocrinology and Metabolism : TEM·David J P Barker
Aug 18, 2000·The Proceedings of the Nutrition Society·C Power, T Parsons
Apr 1, 2010·Journal of Developmental Origins of Health and Disease·D J JaworowiczJ L Freudenheim
Oct 1, 2010·Journal of Developmental Origins of Health and Disease·K PilgaardT Jørgensen
Dec 1, 2012·Journal of Developmental Origins of Health and Disease·B DixonE M Taveras
Jun 19, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·L AyV W V Jaddoe
Jun 10, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·C G OwenD G Cook
Jan 24, 2013·Journal of Exposure Science & Environmental Epidemiology·Leonardo TrasandeGeorge Thurston
Jul 6, 2000·Public Health·R GofinB Adler
Mar 22, 2003·Diabetic Medicine : a Journal of the British Diabetic Association·M S FreemanP J Grant
Oct 28, 2005·The New England Journal of Medicine·Matthew W Gillman
Oct 28, 2005·The New England Journal of Medicine·David J P BarkerJohan G Eriksson
Jul 4, 2008·The New England Journal of Medicine·Peter D GluckmanKent L Thornburg
Feb 20, 2004·Public Health Nutrition·I Darnton-HillW P T James
May 8, 1998·The Proceedings of the Nutrition Society·K Godfrey, S Robinson
May 8, 1998·The Proceedings of the Nutrition Society·P H Whincup
May 11, 2007·American Journal of Epidemiology·Matthew W Gillman, Ken Kleinman
Nov 22, 2008·American Journal of Epidemiology·Hermann NabiArchana Singh-Manoux
Jun 3, 2011·European Heart Journal·Johan G ErikssonDavid J P Barker
Aug 27, 2011·European Heart Journal·Annet F M van AbeelenCuno S P M Uiterwaal
Feb 13, 2008·International Journal of Epidemiology·Eero KajantieJohan G Eriksson
Aug 8, 2008·International Journal of Epidemiology·B AntonisamyCaroline H D Fall
Apr 9, 2009·International Journal of Epidemiology·Kari R RisnesLars J Vatten
May 25, 2006·Clinical Obstetrics and Gynecology·David J P Barker
Sep 7, 2004·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·D J P Barker
Dec 1, 2011·Clinical and Experimental Pharmacology & Physiology·K J BottingJ L Morrison
Jul 23, 1999·BMJ : British Medical Journal·A LucasT J Cole
May 14, 2005·BMJ : British Medical Journal·Johan G Eriksson
Dec 17, 2003·Heart·T ForsénD J P Barker
Jan 15, 2005·Journal of Epidemiology and Community Health·P C ElwoodDavid Davies
Oct 20, 2005·Journal of Epidemiology and Community Health·W A ShultisUNKNOWN ALSPAC Study Team

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.