BIS-guided deep anesthesia decreases short-term postoperative cognitive dysfunction and peripheral inflammation in elderly patients undergoing abdominal surgery

Brain and Behavior
Chengxuan QuanOuyang Wen

Abstract

Postoperative cognitive dysfunction (POCD) is a common clinical complication, with an underlying pathophysiology linked to heightened levels of neuroinflammation. However, it requires clarification as to whether the depth of anesthesia modulates postoperative cognitive dysfunction. This study investigated the association between depth of anesthesia and POCD in elderly patients undergoing abdominal surgery. A total of 120 patients aged 60 years or older who were planned for abdominal surgery under total intravenous anesthesia were included in this study. The depth of anesthesia was guided by monitoring Bispectral Index (BIS) data. All study participants completed a battery of nine neuropsychological tests before surgery and at 7 days and 3 months after surgery. POCD was calculated by using the reliable change index. Plasma concentration of C-reactive protein (CRP), interleukin (IL)-1β, IL-10, S-100β, and norepinephrine (NE) were measured. The incidence of POCD at 7 days after surgery in the deep anesthesia group was 19.2% (10/52), which was significantly lower (p = 0.032) than the light anesthesia group 39.6% (21/53). The depth of anesthesia had no effect on POCD at 3 months after surgery (10.3% vs 14.6%, respectively, p = 0.558...Continue Reading

References

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Citations

Oct 28, 2019·Current Opinion in Psychiatry·Lucia Chinnappa-QuinnPerminder S Sachdev
Dec 22, 2019·Aging Clinical and Experimental Research·Mengrong MiaoJiaqiang Zhang
Mar 28, 2020·Mediators of Inflammation·Xiaoxin ZhouDiansan Su
Nov 26, 2019·Experimental Gerontology·Xianyi LinXin Yu
Dec 8, 2020·Anesthesiology Research and Practice·Kim van SinderenPatrick Schober
Feb 15, 2020·Journal of Geriatric Oncology·Nicolas MottetGeorgios Gakis
Jun 18, 2021·Minerva anestesiologica·Andrea Gentili
Jan 7, 2022·CNS Neuroscience & Therapeutics·Yang LiuTianlong Wang

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