BIS guided sedation with propofol during spinal anaesthesia: influence of anaesthetic level on sedation requirement

British Journal of Anaesthesia
T Ozkan-SeyhanK Akpir

Abstract

In this prospective, clinical study we tested the hypothesis whether two different doses of spinal administered bupivacaine and accordingly, two different levels of spinal anaesthesia can affect the dose requirement of propofol during BIS guided sedation. Fifty women undergoing vaginal hysterectomy (high spinal group, HS) or transvaginal tape (TVT) procedure for urinary incontinence (low spinal group, LS) under spinal anaesthesia were enrolled to the study. In group HS, 17.5 mg and in group LS, 7.5 mg of hyperbaric bupivacaine were given intrathecally. After 15 min to obtain the appropriate level of spinal anaesthesia, propofol infusion was started at a rate of 100 microg kg(-1) min(-1) to reach a BIS level of less than 75 (onset time), and titrated to maintain the BIS value between 65 and 75. Propofol infusion was stopped 45 min after placing the spinal to measure the time to reach a BIS level of 90 (recovery time). Median anaesthetic level was T3 (T1-4) in the HS group and T10 (T9-11) in the LS group. In both the HS and the LS groups, onset time was 226 (47) vs 273 (48) s (P=0.001), recovery time was 234 (47) vs 202 (56) s (P=0.03), total dose of propofol was 2.17 (0.43) vs 3.14 (0.56) mg kg(-1) (P<0.001), respectively. A hig...Continue Reading

Citations

Feb 4, 2012·Journal of Clinical Anesthesia·Antje GottschalkDanja S Groves
Jul 21, 2010·Paediatric Anaesthesia·Yatindra K BatraRajeev Subramanyam
Sep 20, 2011·Korean journal of anesthesiology·Mi Hyeon LeeJang-Ho Song
Jun 7, 2013·Korean journal of anesthesiology·Hwoe-Gyeong OkKyung-Hoon Kim
Nov 28, 2015·Basic & Clinical Pharmacology & Toxicology·Go Un RohDong Woo Han

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