Bis-iridoid and iridoid glycosides: Viral protein R inhibitors from Picrorhiza kurroa collected in Myanmar

Fitoterapia
Nwet Nwet WinHiroyuki Morita

Abstract

Four new bis-iridoid glycosides, saungmaygaosides A-D (1-4), and six known iridoid glycosides (5-10) were isolated from the n-butanol extract of the stems of Picrorhiza kurroa collected in Myanmar. Their structures were elucidated by extensive spectroscopic techniques. All of the isolates were assayed for anti-Vpr activity, using TREx-HeLa-Vpr cells. Among the isolates, saungmaygaoside D (4), sylvestroside IV dimethyl acetal (7), and sweroside (8) were the most potent inhibitors with effective doses of 5 and 10 μM, respectively, without showing any notable cytotoxicities.

Citations

Jan 16, 2019·Chemistry & Biodiversity·Nwet Nwet WinHiroyuki Morita
Mar 19, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alejandro ManchadoNarciso M Garrido
Apr 25, 2020·Journal of Natural Medicines· PremaHiroyuki Morita
Mar 7, 2020·Acta Crystallographica. Section C, Structural Chemistry·Zhaoxia QuFeng Zhao
Jul 2, 2021·Chemical & Pharmaceutical Bulletin·Nwet Nwet WinHiroyuki Morita
Aug 21, 2021·Chemistry & Biodiversity·Nhat Nam HoangHiroyuki Morita

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