Abstract
Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative brain disorder, which is the most common form of dementia. Intensive efforts have been made to find effective and safe treatment against AD. Acetylcholinesterase inhibitors (AChEIs) have been widely used for the treatment of mild to moderate AD. In this study, we investigated the effect of Bis(9)-(-)-Meptazinol (B9M), a novel potential dual-binding acetylcholinesterase (AChE) inhibitor, on learning and memory abilities, as well as the underlying mechanism in the APP/PS1 mouse model of AD. B9M (0.1 μg/kg, 0.3 μg/kg, and 1 μg/kg) was administered by subcutaneous injection into eight-month-old APP/PS1 transgenic mice for four weeks. Morris water maze, nest-building and novel object recognition were used to examine learning and memory ability. Aβ levels and Aβ plaque were evaluated by ELISA and immunochemistry. Our results showed that chronic treatment with B9M significantly improved the cognitive function of APP/PS1 transgenic mice in the Morris water maze test, nest-building test and novel object recognition test. Moreover, B9M improved cognitive deficits in APP/PS1 mice by a mechanism that may be associated with its inhibition of the AChE activity, Aβ p...Continue Reading
References
Sep 28, 2000·Toxicological Sciences : an Official Journal of the Society of Toxicology·T NarahashiE D Levin
Dec 4, 2003·Neurobiology of Aging·Salvatore OddoFrank M LaFerla
Apr 5, 2007·Nature Protocols·Robert M J Deacon
Mar 13, 2008·Journal of Medicinal Chemistry·Qiong XieHongzhuan Chen
Sep 16, 2008·Neurobiology of Aging·Arturas VolianskisMorten S Jensen
Dec 5, 2008·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Sriram VennetiJulia Kofler
Jan 24, 2009·Behavioural Brain Research·Giulio TaglialatelaKelly T Dineley
Sep 2, 2010·Behavioural Brain Research·Daniel W Wesson, Donald A Wilson
Feb 2, 2011·Neuropharmacology·Mohammed FilaliSerge Rivest
Nov 1, 2011·Neuropathology and Applied Neurobiology·R ThangavelA Zaheer
Nov 16, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jennifer L FurmanChristopher M Norris
Dec 25, 2012·Pharmacology, Biochemistry, and Behavior·Ting LiuHong-Zhuan Chen
Aug 22, 2013·Frontiers in Integrative Neuroscience·Marco A Meraz-RíosVictoria Campos-Peña
Mar 19, 2014·Nature Reviews. Neurology·Yan-Jiang Wang
Nov 12, 2014·Current Medicinal Chemistry·Natalia GuziorBarbara Malawska
Jun 13, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Qing-Shan DengRu-Xiang Xu
Oct 18, 2015·Pharmacology, Biochemistry, and Behavior·Ran-Yao YangGuan-Hua Du
Dec 23, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jan KorabecnyKamil Kuca
Jan 21, 2016·Current Neuropharmacology·Yu WangHong-zhuan Chen
Mar 31, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Michalina HebdaBarbara Malawska
Apr 28, 2016·Current Alzheimer Research·Marco MagistriMohammad Ali Faghihi
May 29, 2016·Behavioural Brain Research·Xun-Hu GuWei Wang
Jun 3, 2016·Frontiers in Neuroscience·Mercedes UnzetaJosé Marco-Contelles
Jul 5, 2016·Frontiers in Neuroscience·Katarina NikolicJohn B O Mitchell
Jan 14, 2017·Frontiers in Molecular Neuroscience·Ce Xie, Tomohiro Miyasaka
Jan 28, 2017·Journal of Negative Results in Biomedicine·Sally Hunter, Carol Brayne
Feb 1, 2017·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Sayad Kocahan, Zumrut Doğan
Citations
Jun 24, 2020·Molecular Neurobiology·Yingying HeWeina Yang
Oct 17, 2020·Experimental Neurology·John Bosco RuganzuWeina Yang
Apr 27, 2021·Journal of Alzheimer's Disease : JAD·Wei-Hao LiTie-Qiao Wen
Jun 23, 2021·ACS Chemical Neuroscience·Zhenquan XuanWei Cui