Bisbenzamidines as antifungal agents. are both amidine functions required to observe an anti-Pneumocystis carinii activity?

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Julien LaurentJean Jacques Vanden Eynde

Abstract

A library of 19 novel 4-(4-phenylpiperazine-1-yl)benzamidines has been synthesized and evaluated in vitro against Pneumocystis carinii. Among these compounds, N-ethyl- and N-hexyl-4-(4-phenylpiperazine-1-yl)benzamidines emerged as the most promising compounds, with inhibition percentages at 10.0 microg/mL of 87% and 96%, respectively. Those compounds remained active at 0.1 microg/mL.

References

Dec 2, 1999·Pharmacology & Therapeutics·B S ReddyJ W Lown
Dec 29, 2000·Bioorganic & Medicinal Chemistry Letters·I J SimpsonS Neidle
Mar 18, 2004·Bioorganic & Medicinal Chemistry Letters·Annie MayenceTien L Huang
Sep 11, 2004·Bioorganic & Medicinal Chemistry Letters·Jean Jacques Vanden EyndeMelanie T Cushion
Jul 30, 2005·Expert Opinion on Investigational Drugs·M N C SoeiroD W Boykin
Mar 31, 2009·Cancer Treatment Reviews·Xuemei CaiDaniel D Von Hoff
Sep 9, 2009·Bioorganic & Medicinal Chemistry Letters·Tien L HuangNigel Yarlett

❮ Previous
Next ❯

Citations

May 7, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Guangyou ChenXing Zhang
Feb 4, 2012·European Journal of Medicinal Chemistry·D ForgeJ J Vanden Eynde
Nov 28, 2013·Pharmaceuticals·Dimitri StanickiEl-Moukhtar Aliouat
May 8, 2018·Analytical and Bioanalytical Chemistry·Ioan O NeagaBertrand Blankert

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.