Biscoumarin derivatives from Edgeworthia gardneri that inhibit the lyase activity of DNA polymerase beta

Journal of Natural Products
Shi-Sheng LiSidney M Hecht

Abstract

Bioassay-guided fractionation of an active methyl ethyl ketone extract of Edgeworthia gardneri, using an assay to monitor DNA polymerase beta lyase inhibition, resulted in the isolation of three known biscoumarin derivatives, 7-hydroxy-3,7'-dicoumaryl ether (edgeworin, 1), 7-hydroxy-6-methoxy-3,7'-dicoumaryl ether (daphnoretin, 2), and 6,7-dihydroxy-3,7'-dicoumaryl ether (edgeworthin, 3). Compounds 1-3 inhibited the lyase activity of DNA polymerase beta with IC(50) values of 7.3 microg/mL (22.5 microM), 43.0 microg/mL (122.3 microM), and 32.1 microg/mL (94.8 microM), respectively.

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Citations

Sep 5, 2015·Journal of Agricultural and Food Chemistry·Yan-Yan MaKun Zhang
Sep 3, 2016·Genes·Elisa MentegariEmmanuele Crespan
Jan 10, 2017·Chemical Research in Toxicology·A S Prakasha GowdaThomas E Spratt
Aug 14, 2019·Bioorganic Chemistry·Uzma SalarM Iqbal Choudhary
Aug 11, 2020·Bioorganic & Medicinal Chemistry·Sasha M DaskalovaSidney M Hecht
Aug 22, 2006·Bioorganic & Medicinal Chemistry·Muhammad Iqbal Choudhary Atta-Ur-Rahman
Mar 18, 2008·Bioorganic & Medicinal Chemistry·Zhijie GaoSidney M Hecht

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