Abstract
Bioassay-guided fractionation of an active methyl ethyl ketone extract of Edgeworthia gardneri, using an assay to monitor DNA polymerase beta lyase inhibition, resulted in the isolation of three known biscoumarin derivatives, 7-hydroxy-3,7'-dicoumaryl ether (edgeworin, 1), 7-hydroxy-6-methoxy-3,7'-dicoumaryl ether (daphnoretin, 2), and 6,7-dihydroxy-3,7'-dicoumaryl ether (edgeworthin, 3). Compounds 1-3 inhibited the lyase activity of DNA polymerase beta with IC(50) values of 7.3 microg/mL (22.5 microM), 43.0 microg/mL (122.3 microM), and 32.1 microg/mL (94.8 microM), respectively.
References
Jan 1, 1986·Carcinogenesis·S Seki, T Oda
Dec 1, 1988·Carcinogenesis·S Seki, T Oda
Nov 28, 1989·Biochemistry·J A DiGiuseppe, S L Dresler
Oct 11, 1995·Nucleic Acids Research·J K HortonS H Wilson
Jan 1, 1994·Journal of Cellular Biochemistry·F Ali-OsmanD E Stein
Jan 11, 1996·Nature·R W SobolS H Wilson
Aug 2, 1996·The Journal of Biological Chemistry·S NarayanS H Wilson
Feb 26, 1998·Cell·T A Baker, S P Bell
Feb 5, 2000·Journal of Molecular Biology·M W MaciejewskiG P Mullen
May 23, 2000·Natural Product Reports·D Ferreira, X C Li
Jun 24, 2000·Nature·R W SobolS H Wilson
Feb 15, 2001·Biochemistry·A J PodlutskyG L Dianov
Mar 21, 2001·Nature Reviews. Genetics·D C van GentR Kanaar
Dec 1, 2001·The EMBO Journal·S L AllinsonG L Dianov
Feb 21, 2002·The International Journal of Biochemistry & Cell Biology·Haitham T IdrissSamuel H Wilson
Jun 5, 2002·Annual Review of Biochemistry·Ulrich HubscherSilvio Spadari
Jan 2, 2003·DNA Repair·Julie K HortonSamuel H Wilson
Jan 2, 2003·DNA Repair·Julie K HortonSamuel H Wilson
Jan 16, 2003·Nucleic Acids Research·Assen MarintchevGregory P Mullen
Apr 26, 2003·DNA Repair·Robert W SobolSamuel H Wilson
Jul 10, 2003·Angewandte Chemie·Orlando D Schärer
Aug 21, 2003·Journal of Molecular Biology·Valérie BergoglioJean Sébastien Hoffmann
Citations
Sep 5, 2015·Journal of Agricultural and Food Chemistry·Yan-Yan MaKun Zhang
Sep 3, 2016·Genes·Elisa MentegariEmmanuele Crespan
Jan 10, 2017·Chemical Research in Toxicology·A S Prakasha GowdaThomas E Spratt
May 11, 2006·Phytotherapy Research : PTR·Bo-Young ParkHyeong-Kyu Lee
Aug 14, 2019·Bioorganic Chemistry·Uzma SalarM Iqbal Choudhary
Aug 11, 2020·Bioorganic & Medicinal Chemistry·Sasha M DaskalovaSidney M Hecht
Aug 22, 2006·Bioorganic & Medicinal Chemistry·Muhammad Iqbal Choudhary Atta-Ur-Rahman
Oct 11, 2014·Chemical Reviews·Ramendra Pratap, Vishnu Ji Ram
Mar 18, 2008·Bioorganic & Medicinal Chemistry·Zhijie GaoSidney M Hecht