Abstract
Laminin-332 (Lm332; formerly laminin-5) is a basement membrane protein in the skin, which promotes cell motility in wound healing and cancer invasion. In a previous study, we reported that the introduction of bisecting GlcNAc into Lm332 (GnT-III-Lm332), catalyzed by N-acetylglucosaminyltransferase III (GnT-III), reduced cell migration (Kariya, Y., Kato, R., Itoh, S., Fukuda, T., Shibukawa, Y., Sanzen, N., Sekiguchi, K., Wada, Y., Kawasaki, N., and Gu, J. (2008) J. Biol. Chem. 283, 33036-33045). However, the underlying molecular mechanism by which GnT-III-Lm332 suppresses the normal biological functions of Lm332 remains to be elucidated. In this study, we show that galectin-3, which is a beta-galactoside-binding protein, strongly bound to unmodified Lm332 but not to GnT-III-Lm332 and that binding of galectin-3 was completely blocked by lactose. Exogenous galectin-3 significantly enhanced keratinocyte cell motility on control Lm332 but not on GnT-III-Lm332. A functional blocking antibody against galectin-3 inhibited Lm332-induced alpha3beta1 and alpha6beta4 integrin clustering and focal contact formation. Co-immunoprecipitation revealed that galectin-3 associated with both beta4 integrin and epidermal growth factor receptor, ther...Continue Reading
References
Aug 1, 1991·The Journal of Cell Biology·P RousselleR E Burgeson
May 1, 1991·The Journal of Cell Biology·A SonnenbergM Loizidou
May 17, 1991·Cell·W G CarterP J Gahr
Jun 1, 1988·The Biochemical Journal·S FujiwaraR Timpl
Mar 1, 1986·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·H Schachter
Sep 12, 1995·Proceedings of the National Academy of Sciences of the United States of America·M YoshimuraN Taniguchi
Nov 15, 1994·Genomics·L PulkkinenJ Uitto
Mar 1, 1994·Nature Genetics·D AberdamJ P Ortonne
Jul 1, 1996·Journal of Cellular Physiology·N Le Marer, R C Hughes
Jun 7, 1996·The Journal of Biological Chemistry·M YoshimuraN Taniguchi
Jun 10, 1998·Biochemical and Biophysical Research Communications·J OchiengP Warfield
Aug 26, 1998·The American Journal of Pathology·S Hirohashi
Sep 10, 1998·The Journal of Cell Biology·K M Hodivala-DilkeR O Hynes
Mar 4, 2000·International Journal of Cancer. Journal International Du Cancer·P MatarreseS Iacobelli
Mar 4, 2000·Nature Medicine·M GranovskyJ W Dennis
Jun 8, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·H Colognato, P D Yurchenco
Aug 6, 2000·The Journal of Biological Chemistry·B P NguyenW G Carter
May 25, 2001·The Journal of Biological Chemistry·A UtaniH Shinkai
Oct 31, 2001·The Journal of Cell Biology·A MariottiF G Giancotti
Dec 12, 2001·Biochemical and Biophysical Research Communications·V FurtakJ Ochieng
Jan 5, 2002·Proceedings of the National Academy of Sciences of the United States of America·Sen-itiroh Hakomori Si
Aug 27, 2002·The Journal of Biological Chemistry·Zhiyi CaoNoorjahan Panjwani
Dec 10, 2002·International Journal of Cancer. Journal International Du Cancer·Axel HitteletIsabelle Camby
Jan 18, 2003·Journal of Cellular Biochemistry·Yoshinobu KariyaKaoru Miyazaki
Feb 7, 2003·Nature·Maya DajeePaul A Khavari
Jul 17, 2003·Journal of Cell Science·Alan J RussellM Peter Marinkovich
Aug 30, 2003·The Journal of Biological Chemistry·Osamu OkamotoPatricia Rousselle
Oct 1, 2003·The Journal of Cell Biology·Laurent Gagnoux-PalaciosFilippo G Giancotti
Oct 17, 2003·The Journal of Biological Chemistry·Hua-Bei GuoMichael Pierce
Oct 25, 2003·Glycobiology·Jianguo GuNaoyuki Taniguchi
Dec 5, 2003·Biochimica Et Biophysica Acta·Ewa PochećAnnarita Casbarra
Dec 6, 2003·Science·Anne J RidleyAlan Rick Horwitz
Mar 5, 2004·The Journal of Biological Chemistry·Tomoya IsajiNaoyuki Taniguchi
Jun 8, 2004·Molecular Biology of the Cell·Jun-ichi FukushiWilliam B Stallcup
Jun 24, 2004·Experimental Cell Research·Yoshinobu Kariya, Kaoru Miyazaki
Oct 2, 2004·Science·Emily A PartridgeJames W Dennis
Dec 22, 2004·The Journal of Cell Biology·Xiuwei YangMartin E Hemler
Feb 25, 2005·International Journal of Cancer. Journal International Du Cancer·Claudia ParetMargot Zöller
Jun 14, 2005·Biochimica Et Biophysica Acta·Linda J Pike
Jan 31, 2006·Cancer Science·Kaoru Miyazaki
Feb 16, 2006·Biochimica Et Biophysica Acta·Jerka DumicMirna Flögel
Mar 16, 2006·The Journal of Biological Chemistry·Junko IijimaJianguo Gu
Aug 31, 2006·The Journal of Biological Chemistry·Yanyang ZhaoJianguo Gu
Sep 9, 2006·The Journal of Biological Chemistry·Tomoya IsajiJianguo Gu
Dec 5, 2006·Proceedings of the National Academy of Sciences of the United States of America·Seon-Joo YoonSen-itiroh Hakomori
Apr 26, 2007·Nature Reviews. Cancer·M Peter Marinkovich
May 15, 2007·Cellular and Molecular Life Sciences : CMLS·M T ElolaG A Rabinovich
Sep 8, 2007·Trends in Pharmacological Sciences·Filippo G Giancotti
Oct 24, 2007·Current Opinion in Structural Biology·Gabriel A RabinovichGerardo R Vasta
Aug 5, 2008·The Journal of Biological Chemistry·Ya ZhuoSusan L Bellis
Citations
Apr 6, 2012·Glycoconjugate Journal·Hazuki E MiwaPamela Stanley
May 9, 2012·Glycoconjugate Journal·Jianguo GuYuguang Du
Mar 28, 2012·The Journal of Biological Chemistry·Qingsong XuJianguo Gu
Oct 5, 2010·PloS One·Kevin A MaupinBrian B Haab
Nov 11, 2011·PloS One·Yoshinobu Kariya, Jianguo Gu
Jan 5, 2012·PloS One·Fabiana H M MeloRoger Chammas
May 9, 2012·PloS One·Yoshinobu KariyaKaoru Miyazaki
Feb 16, 2013·Journal of Dermatological Science·Hiroshi KogaTakashi Hashimoto
Sep 6, 2011·Journal of Dermatological Science·Larissa LarsenFu-Tong Liu
May 28, 2011·Current Opinion in Cell Biology·Cecile BoscherIvan R Nabi
Apr 20, 2011·Acta histochemica·Neela D S Rambaruth, Miriam V Dwek
Jul 13, 2012·The Journal of Investigative Dermatology·Wei LiuFu-Tong Liu
Oct 10, 2015·Tissue Barriers·Pablo ArgüesoYuichi Uchino
Aug 21, 2015·Nature Reviews. Cancer·Salomé S Pinho, Celso A Reis
Sep 21, 2013·ISRN Inflammation·Cláudia Danella PolliGabriela Pereira-da-Silva
Jun 15, 2015·Experimental Eye Research·Atsuko FujiiMitsuyoshi Azuma
Sep 20, 2016·Scientific Reports·Qinglei HangJianguo Gu
Jul 6, 2017·Cancers·Yoshinobu KariyaJianguo Gu
Jan 1, 2013·Vaccines·Behjatolah Monzavi-KarbassiThomas Kieber-Emmons
Jun 4, 2017·Molecular & Cellular Proteomics : MCP·Jara ObermannStefanie M Hauck
Dec 8, 2015·Clinical Medicine Insights. Oncology·Hafiz Ahmed, Dina M M AlSadek
Oct 13, 2017·Chembiochem : a European Journal of Chemical Biology·Johann DionCyrille Grandjean
Aug 28, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sicong HouJianguo Gu
May 1, 2019·Medical Oncology·Ling TangXiang Chen
May 24, 2017·Oncotarget·Sofia Nascimento Dos SantosEmerson Soares Bernardes
Sep 17, 2020·Microbial Cell Factories·Wen SongGuimin Zhang
Nov 3, 2012·The Journal of Biological Chemistry·Coert MargadantArnoud Sonnenberg
Jul 3, 2020·Frontiers in Oncology·Lanming ChengZengqi Tan
Jan 19, 2020·Nature Communications·Silvia GianniniKarin M Hoffmeister
Mar 20, 2019·Journal of Cellular Physiology·Chun-Hong LiaoXin-Min Yin
Mar 20, 2018·Molecular Cancer Research : MCR·Yukiko KariyaYoshinobu Kariya
Dec 21, 2019·Biochemical and Biophysical Research Communications·Sicong HouJianguo Gu
Dec 12, 2020·Journal of Extracellular Vesicles·Zengqi TanFeng Guan
May 16, 2014·Journal of Cell Science·Jerome MaurisPablo Argüeso
May 14, 2020·Oncology Research and Treatment·Chenglong LiYuan Ruan
Jan 16, 2022·Inflammation·Mab P CorrêaCristiane D Gil