Bisoprolol and captopril effects on insulin receptor tyrosine kinase activity in essential hypertension

American Journal of Hypertension
L J DominguezJ R Sowers

Abstract

Angiotension converting enzyme (ACE) inhibitors and beta-blockers have been reported to possess disparate effects on insulin sensitivity. The aim of this study was to study the effects of the selective beta-1 blocker bisoprolol and of the ACE inhibitor captopril on cellular insulin action in hypertensive individuals. After washout, 12 mild to moderate essential hypertensives were randomized in a double-blind manner to 5 mg bisoprolol daily or 25 mg captopril twice daily for 8 weeks. Erythrocyte insulin binding and insulin-stimulated tyrosine kinase (TK) activity were measured before and after therapy. Both agents decreased diastolic blood pressure significantly (bisoprolol 96.5+/-0.9 to 87.8+/-3.1 mm Hg; captopril 96.5+/-0.9 to 91.5+/-1.8 mm Hg; P < .05). Fasting plasma glucose, insulin, and insulin/glucose indices remained unchanged after both therapies, as did lipid profiles. Maximal insulin-stimulated TK activity, assessed by phosphorylation of the exogenous substrate poly-Glu80Tyr20, was significantly higher (P < .05) after bisoprolol treatment, but not after captopril treatment, when compared to placebo (bisoprolol 8.5+/-1.8; captopril 7.3+/-1.5; placebo: 6.4+/-1.3 pmol 32P-ATP/fmol bound insulin). However, captopril, but ...Continue Reading

Citations

Mar 20, 2003·Current Diabetes Reports·Kambiz Kalantarinia, Helmy M Siragy
Mar 18, 2011·Current Medical Research and Opinion·B TomlinsonF Follath
May 7, 2002·American Journal of Hypertension·Dalila B CorryMichael L Tuck
Jan 28, 2012·Cardiovascular Therapeutics·Dennis LadageKlara Brixius
Mar 31, 2017·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Csaba András Dézsi, Veronika Szentes
Mar 21, 2003·Metabolism: Clinical and Experimental·Regina S MoisésMario J A Saad

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