PMID: 8581388Oct 1, 1995Paper

Bispecific antibodies as targeting agents for boron neutron capture therapy of brain tumors

Journal of Hematotherapy
L LiuR A Reisfeld

Abstract

Boron neutron capture therapy (BNCT) is based on the nuclear reaction that occurs when boron-10, a stable isotope, is irradiated with low energy (< or = 0.025 eV) or thermal neutrons to yield alpha particles and recoiling lithium-7 nuclei. A major requirement for the success of BNCT is the selective delivery of a sufficient number of boron atoms (approximately 10(9)) to individual cancer cells to sustain a lethal 10B (n, alpha) 7Li capture reaction. A panel of BsAb reactive with polyhedral borane anions (PBA) and a tumor-associated chondroitin sulfate proteoglycan has been produced. All of these BsAb showed strong reactivity with a panel of human glioblastoma and melanoma cell lines, as demonstrated by indirect membrane immunofluorescence. Two of them (H6 and B8) also reacted with cells that had been exposed to PBA (Na2B10H10 and Na2B12H11SH) and a boronated starburst dendrimer, which contained approximately 250-400 B atoms per molecule. The affinity constant (Ka) of BsAb-B8 was 2.57 x 10(8) M-1 on M21 human melanoma cell and 3.49 x 10(8) M-1 on A172 glioblastoma cells, which were almost identical to those of the parental monoclonal antibody (mAb) 9.2.27 on the same cell lines (2.62 x 10(8) M-1). Since our BsAb recognize both h...Continue Reading

References

Feb 28, 1978·Biochemical and Biophysical Research Communications·P J Fraker, J C Speck
Apr 19, 1989·Journal of the National Cancer Institute·R K Jain
Jun 1, 1987·The British Journal of Radiology·A T VaughanA R Bradwell
Jul 18, 1995·Proceedings of the National Academy of Sciences of the United States of America·R H PakM F Hawthorne
Jan 1, 1993·Cancer Treatment and Research·M W FangerP M Guyre

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Citations

Jun 7, 2005·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·E HerreraA Delfín Loya
Mar 4, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·R L GutmanD R Lu
Feb 5, 2003·Advanced Drug Delivery Reviews·Ying Cao, Laura Lam
Jun 6, 2000·Advanced Drug Delivery Reviews· de Leij LB J Kroesen
May 8, 1998·Molecular Medicine Today·M F Hawthorne
Oct 1, 2011·Drug Development and Industrial Pharmacy·Shadabul HaqueSanjula Baboota
Apr 23, 2008·Expert Opinion on Drug Delivery·Hironobu YanagiëHiroyuki Takahashi
Jul 12, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Abdel-Kareem AzabAbraham Rubinstein
Jul 28, 2016·Journal of Cancer Research and Therapeutics·Hamid Reza MirzaeiHamed Mirzaei
May 17, 2003·Journal of Neuro-oncology·Jörgen CarlssonLars Gedda
Sep 20, 2005·Molecular Cancer Therapeutics·Marina V BackerJoseph M Backer
Jun 3, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Rolf F BarthThomas E Blue
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Martin KellertEvamarie Hey-Hawkins
Sep 1, 1996·Bioconjugate Chemistry·F J PrimusM F Hawthorne
Feb 19, 2002·Chemical Reviews·M. Frederick Hawthorne, Andreas Maderna
Feb 19, 2002·Chemical Reviews·Albert H. SolowayJ. Gerald Wilson

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