PMID: 9447852Feb 3, 1998Paper

Bispectral analysis of the electroencephalogram predicts conscious processing of information during propofol sedation and hypnosis

Anesthesiology
L A KearseW T Denman

Abstract

The bispectral index (BIS) measures changes in the interfrequency coupling of the electroencephalogram (EEG). The purposes of this study were (1) to determine whether BIS correlates with responses to command during sedation and hypnosis induced by propofol or propofol and nitrous oxide, and (2) to compare BIS to targeted and measured concentrations of propofol in predicting participants' responses to commands. Twenty volunteers (15 men and 5 women, aged 22-50 yr) were given propofol by computer-controlled infusion, and EEG was recorded for off-line analysis of BIS. Responses to randomly ordered verbal commands or voice plus touch were measured with two categorical scales (CS1 and CS2, respectively). All subjects received a propofol infusion targeted to achieve effect site concentrations of 1, 2, 4, 2, 1, and 0 microg/ml. Ten participants had repeated infusion, whereas 10 others breathed 30% nitrous oxide and oxygen and received a propofol infusion targeted for 0.5, 1, 2, 4, 2, 1, 0.5, and 0 microg/ml. Five minutes after each targeted concentration had been reached, CS1, CS2, and arterial propofol concentration were determined. The area under the receiver operating characteristic curve was used to compare the accuracy of (1) BIS...Continue Reading

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Citations

Oct 3, 1999·Medical & Biological Engineering & Computing·X S Zhang, R J Roy
Nov 7, 2002·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Mio ShinozakiToshimitsu Kitajima
Jun 1, 2000·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·G LafreniereJ L Parlow
Jun 29, 2002·Journal of Clinical Anesthesia·Chi-Chen WuMartin S Mok
Jul 27, 2001·Acta Anaesthesiologica Scandinavica·G BarrJ G Jakobsson
Jul 26, 2002·Acta Anaesthesiologica Scandinavica·H MäättänenJ Jakobsson
Feb 15, 2000·Anaesthesia·B Thøgersen, H Ording
Feb 13, 2002·Critical Care Medicine
Aug 7, 2002·Critical Care Medicine·Hermann J TheilenMaximilian Ragaller
Jun 10, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Noreen CrainMurray M Pollack
Sep 17, 2003·Critical Care : the Official Journal of the Critical Care Forum·Joseph Varon, Paul E Marik
Mar 11, 1999·Anesthesia and Analgesia·J W SleighM Steyn-Ross
Jan 5, 2002·Anesthesia and Analgesia·Diederik NieuwenhuijsAlbert Dahan
Jul 23, 2003·Anesthesia and Analgesia·M MessnerK Tschaikowsky
Jan 27, 2004·Anesthesia and Analgesia·Ariane K LewisRam Roth
May 25, 2004·Anesthesia and Analgesia·Simon D Whyte, Peter D Booker
Mar 23, 2006·Anesthesia and Analgesia·Dharshi KaralapillaiAndrew R Bjorksten

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