Bispectral index for improving anaesthetic delivery and postoperative recovery

The Cochrane Database of Systematic Reviews
Y PunjasawadwongNutchanart Bunchungmongkol


The use of clinical signs may not be reliable in measuring the hypnotic component of anaesthesia. The use of bispectral index (BIS) to guide the dose of anaesthetic may have certain advantages over clinical signs. This is the second update of a review originally published in 2007. The primary objective of this review focused on whether the incorporation of BIS into the standard practice for management of anaesthesia can reduce the risk of intraoperative awareness, consumption of anaesthetic agents, recovery time and total cost of anaesthesia in surgical patients undergoing general anaesthesia. In this updated version, we searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2013, Issue 1), MEDLINE (1990 to 31 January 2013), EMBASE (1990 to 31 January 2013) and reference lists of articles. Previously, we searched to May 2009. We included randomized controlled trials comparing BIS with standard practice criteria for titration of anaesthetic agents. Two authors independently assessed trial quality, extracted data and analysed the data. We contacted study authors for further details. We included 36 trials. In studies using clinical signs as standard practice, the results demonstrated a signific...Continue Reading


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