Bispectral index-guided administration of anaesthesia: comparison between remifentanil/propofol and remifentanil/isoflurane

European Journal of Anaesthesiology
G SchneiderP S Sebel


The bispectral index of the electroencephalogram is a measure of the hypnotic component of anaesthesia and can be used to guide the administration of anaesthesia. This study compares bispectral index-guided anaesthesia with remifentanil and either propofol or isoflurane. Eighty consenting patients were randomly assigned to two groups. Following induction with propofol and remifentanil, anaesthesia was maintained with remifentanil/propofol or remifentanil/isoflurane. Remifentanil infusion rates were guided by haemodynamic responses--maintaining mean arterial pressure and heart rate within 20% of baseline. Propofol and isoflurane administration was guided using the bispectral index (45-60). Thirty minutes before the end of surgery, morphine was administered (0.15 mg kg(-1) intravenously). Fifteen minutes before end of surgery, propofol and isoflurane were reduced (bispectral index 60-75). At the end of surgery, the anaesthetic agents were discontinued. Groups were compared for recovery, remifentanil doses and signs of inadequate anaesthesia using the chi2-test and ANOVA (P < 0.05). The duration of surgery was longer in the propofol/remifentanil group (121 +/- 53 versus 94 +/- 40 min). Recovery data were not different between grou...Continue Reading


Jun 1, 1991·Anaesthesia·W H LiuA R Aitkenhead
Jun 1, 1981·British Journal of Pharmacology·D Lawrence, A Livingston
Dec 1, 1993·Anesthesiology·J F Antognini, K Schwartz
May 1, 1997·European Journal of Anaesthesiology. Supplement·G Schneider, P S Sebel
Oct 20, 1998·Anesthesiology·I J Rampil
Jan 10, 2002·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Jean WongFrances Chung
Feb 28, 2002·Anesthesia and Analgesia·Brian FredmanPaul F White

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