Bisphenol-A affects male fertility via fertility-related proteins in spermatozoa

Scientific Reports
Md Saidur RahmanMyung-Geol Pang

Abstract

The xenoestrogen bisphenol-A (BPA) is a widespread environmental contaminant that has been studied for its impact on male fertility in several species of animals and humans. Growing evidence suggests that xenoestrogens can bind to receptors on spermatozoa and thus alter sperm function. The objective of the study was to investigate the effects of varying concentrations of BPA (0.0001, 0.01, 1, and 100 μM for 6 h) on sperm function, fertilization, embryonic development, and on selected fertility-related proteins in spermatozoa. Our results showed that high concentrations of BPA inhibited sperm motility and motion kinematics by significantly decreasing ATP levels in spermatozoa. High BPA concentrations also increased the phosphorylation of tyrosine residues on sperm proteins involved in protein kinase A-dependent regulation and induced a precocious acrosome reaction, which resulted in poor fertilization and compromised embryonic development. In addition, BPA induced the down-regulation of β-actin and up-regulated peroxiredoxin-5, glutathione peroxidase 4, glyceraldehyde-3-phosphate dehydrogenase, and succinate dehydrogenase. Our results suggest that high concentrations of BPA alter sperm function, fertilization, and embryonic deve...Continue Reading

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Citations

Jun 7, 2016·Reproduction in Domestic Animals = Zuchthygiene·E TvrdáN Lukáč
Aug 11, 2016·BMC Genomics·Md Saidur RahmanMyung-Geol Pang
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Apr 9, 2017·Molecular Reproduction and Development·Md Saidur RahmanMyung-Geol Pang
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Jul 25, 2019·Scientific Reports·Md Saidur RahmanMyung-Geol Pang
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May 30, 2020·Reproductive Biology and Endocrinology : RB&E·Hedvika ŘimnáčováJan Nevoral
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Methods Mentioned

BETA
Assay

Software Mentioned

SPSS
Quantity One
SAIS
Pathway Studio

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