Bisphenol-A and metabolic diseases: epigenetic, developmental and transgenerational basis

Environmental Epigenetics
Paloma Alonso-MagdalenaCarlos Guerrero-Bosagna

Abstract

Exposure to environmental toxicants is now accepted as a factor contributing to the increasing incidence of obesity and metabolic diseases around the world. Such environmental compounds are known as 'obesogens'. Among them, bisphenol-A (BPA) is the most widespread and ubiquitous compound affecting humans and animals. Laboratory animal work has provided conclusive evidence that early-life exposure to BPA is particularly effective in predisposing individuals to weight gain. Embryonic exposure to BPA is reported to generate metabolic disturbances later in life, such as obesity and diabetes. When BPA administration is combined with a high-fat diet, there is an exacerbation in the development of metabolic disorders. Remarkably, upon BPA exposure of gestating females, metabolic disturbances have been found both in the offspring and later in life in the mothers themselves. When considering the metabolic effects generated by an early developmental exposure to BPA, one of the questions that arises is the role of precursor cells in the etiology of metabolic disorders. Current evidence shows that BPA and other endocrine disruptors have the ability to alter fat tissue development and growth by affecting the capacity to generate functional ...Continue Reading

References

Dec 10, 1998·The Journal of Endocrinology·P Sohoni, J P Sumpter
Apr 2, 1999·Science·M F PittengerD R Marshak
Nov 5, 1999·Nature·K L HowdeshellF S vom Saal
Nov 5, 2002·The Journal of Clinical Endocrinology and Metabolism·Kenji MoriyamaKazuwa Nakao
Jan 22, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Hiroshi MasunoKatsuhisa Honda
Apr 20, 2005·Lancet·Robert H EckelPaul Z Zimmet
May 10, 2006·Diabetic Medicine : a Journal of the British Diabetic Association·K G M M AlbertiJ Shaw
Sep 9, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Martin J HoogduijnPaul G Genever
Mar 17, 2007·Nature Reviews. Genetics·Randy L Jirtle, Michael K Skinner
Oct 17, 2007·Journal of Atherosclerosis and Thrombosis·Joji MiyawakiHiroshi Masuno
Feb 21, 2009·Journal of Cellular Biochemistry·Zhao-Jun LiuOmaida C Velazquez
May 13, 2009·Molecular and Cellular Endocrinology·Felix Grün, Bruce Blumberg
Jun 9, 2009·Endocrine Reviews·Evanthia Diamanti-KandarakisAndrea C Gore
Jul 2, 2009·Cytotherapy·Jyoti A KodeAnandwardhan A Hardikar
Dec 19, 2009·Environmental Health Perspectives·Emmanuel SommPetra S Hüppi
Jan 16, 2010·Trends in Endocrinology and Metabolism : TEM·Michael K SkinnerCarlos Guerrero-Bosagna
Mar 27, 2010·Environmental Health Perspectives·Laura N VandenbergGilbert Schoenfelder
May 22, 2010·Environmental Health Perspectives·Paloma Alonso-MagdalenaAngel Nadal
Mar 23, 2011·Birth Defects Research. Part C, Embryo Today : Reviews·Amanda Janesick, Bruce Blumberg
Apr 7, 2011·Nature Reviews. Endocrinology·Paloma Alonso-MagdalenaAngel Nadal
Sep 14, 2011·Reproduction : the Official Journal of the Society for the Study of Fertility·Marta Teperek-TkaczAnne C Ferguson-Smith
Dec 27, 2011·Biochemical and Biophysical Research Communications·Ronald BiemannBernd Fischer
Jan 5, 2012·Environmental Health Perspectives·Yipeng SuiChangcheng Zhou
Jan 5, 2012·Nature Reviews. Genetics·Robert Feil, Mario F Fraga
Jan 10, 2012·Molecular and Cellular Endocrinology·Paloma Alonso-MagdalenaÁngel Nadal
Mar 12, 2013·Journal of Pregnancy·Bonnie BrensekeJ Claudio Gutierrez
Apr 18, 2013·PLoS Genetics·Martha SusiarjoMarisa S Bartolomei

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Citations

Jun 2, 2020·Birth Defects Research·Sanjay BasakAsim K Duttaroy
Apr 22, 2020·Dose-response : a Publication of International Hormesis Society·Wentao WuYan Hong
Mar 23, 2020·Environmental Toxicology and Pharmacology·Muhammad Sajid Hamid AkashKanwal Rehman
May 1, 2021·Antioxidants·Stefano LorenzettiInga C Teller

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