Bisphenol A exposure may increase the risk of development of atopic disorders in children

International Journal of Hygiene and Environmental Health
I-Jen WangCarl-Gustaf Bornehag

Abstract

Little is known about the effect of Bisphenol A (BPA) on atopic disorders. To investigated the associations (i) between postnatal BPA exposure and allergic diseases in children; (ii) between BPA and IgE levels for the possible disease pathogenesis; and (iii) gender-based differences. A total of 453 children from Childhood Environment and Allergic Diseases Study cohort with urine and blood samples were recruited in Taiwan. Urinary BPA glucoronide (BPAG) levels were measured by UPLC-MS/MS at ages 3 and 6 years. The associations between BPAG levels at different ages and IgE levels and the development of allergic diseases were evaluated by multivariate linear regression and logistic regression. A mediation analysis was also conducted to evaluate how much risk of allergic diseases in relation to BPA exposure is explained by IgE changes. The BPAG levels at age 3 were positively associated with IgE levels at age 3 (β=64.85kU/l per ln-unit increase BPAG level; 95% CI, 14.59-115.11kU/l). Stratified by gender, BPAG levels at age 3 were positively associated with IgE levels at age 3, particularly in girls (β=139.23kU/l; 95% CI, 57.38-221.09kU/l). Similar results were also found at age 6. Urinary BPAG levels at age 3 were significantly ass...Continue Reading

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Citations

May 31, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Risako Tajiki-NishinoTomoki Fukuyama
Feb 8, 2018·Allergy, Asthma & Immunology Research·Tien Jen LinI Jen Wang
Feb 12, 2019·Asia Pacific Allergy·Motoko Mitsui-IwamaYukihiro Ohya
Sep 11, 2020·Human & Experimental Toxicology·A NalbantoğluB Nalbantoğlu
Dec 29, 2018·Autoimmunity·Gali AljadeffYehuda Shoenfeld
Jan 8, 2020·International Journal of Environmental Research and Public Health·Chia-Feng YangI-Jen Wang
Aug 2, 2020·The Journal of Allergy and Clinical Immunology·Lesliam Quirós-AlcaláElizabeth C Matsui
Jul 13, 2019·Environmental Research·Ya MaHuizhen Zhang
Sep 17, 2017·The Science of the Total Environment·Carlos Barrios-EstradaRoberto Parra-Saldívar

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