Bisphenol A in eggs causes development-specific liver molecular reprogramming in two generations of rainbow trout

Scientific Reports
Bastien SadoulMathilakath M Vijayan

Abstract

Bisphenol A (BPA) is widely used in the manufacture of plastics and epoxy resins and is prevalent in the aquatic environment. BPA disrupts endocrine pathways in fish, but the long-term developmental implications are unknown. We demonstrate that BPA deposition in the eggs of rainbow trout (Oncorhynchus mykiss), an ecologically and economically important species of fish, reprograms liver metabolism in the offspring and alters the developmental growth trajectory in two generations. Specifically, BPA reduces growth during early development, followed by a catch-up growth post-juveniles. More importantly, we observed a developmental shift in the liver transcriptome, including an increased propensity for protein breakdown during early life stages to lipid and cholesterol synthesis post- juveniles. The liver molecular responses corresponded with the transient growth phenotypes observed in the F1 generation, and this was also evident in the F2 generation. Altogether, maternal and/or ancestral embryonic exposure to BPA affects liver metabolism leading to development-distinct effects on growth, underscoring the need for novel risk assessment strategies for this chemical in the aquatic environment. This is particularly applicable to migrat...Continue Reading

References

Jun 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D StåhlbergK Einarsson
May 23, 2000·Nature·F S ChapinS Díaz
Jun 12, 2001·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·M KishidaG V Callard
Dec 10, 2002·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Gary H ThorgaardYniv Palti
Jan 13, 2006·Chemosphere·Sarah J BrennanAndrew M Fogarty
Mar 16, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Mathilakath M VijayanEven H Jørgensen
Jul 21, 2006·Nature·José M MontoyaRicard V Solé
Feb 27, 2007·General and Comparative Endocrinology·A MandichL Viganò
Aug 3, 2007·Proceedings of the National Academy of Sciences of the United States of America·Dana C DolinoyRandy L Jirtle
May 16, 2008·Biometrical Journal. Biometrische Zeitschrift·Torsten HothornPeter Westfall
Mar 18, 2009·Bioinformatics·Cole TrapnellSteven L Salzberg
Jun 17, 2009·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Jörg OehlmannCharles R Tyler
Dec 6, 2008·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·Kristina M MillerScott G Hinch
Apr 27, 2010·Reproductive Toxicology·Michele Avissar-WhitingCarmen J Marsit
May 18, 2011·Journal of Lipid Research·Akira HondaYasushi Matsuzaki
Apr 7, 2012·Journal of Environmental Management·Shelby FlintElizabeth Wallace
Jun 19, 2012·Endocrinology·Jennifer T WolstenholmeJessica J Connelly
Jan 1, 2013·BMC Genomics·Paul GeeleherCathal Seoighe
Apr 18, 2013·PLoS Genetics·Martha SusiarjoMarisa S Bartolomei
May 28, 2013·Journal of Lipid Research·Mari HashimotoKan Chiba
Nov 26, 2013·Neurotoxicology and Teratology·Sofiane BoudaliaMarie-Chantal Canivenc-Lavier
Jan 5, 2014·The Journal of Cell Biology·Charles Betz, Michael N Hall
Mar 19, 2014·Environmental Toxicology and Pharmacology·Jaromir Michałowicz
Feb 11, 2015·Aquatic Toxicology·Oana BirceanuMathilakath M Vijayan
Mar 17, 2015·Toxicology and Applied Pharmacology·Ayelet Ziv-GalJodi A Flaws
Mar 26, 2015·Endocrinology·Martha SusiarjoMarisa S Bartolomei
Sep 24, 2015·Aquatic Toxicology·Oana BirceanuMathilakath M Vijayan
Dec 18, 2015·Dose-response : a Publication of International Hormesis Society·Laura Canesi, Elena Fabbri
Jan 8, 2016·Dose-response : a Publication of International Hormesis Society·Filippo AcconciaMaria Marino
Feb 26, 2016·Scientific Reports·Stefania SantangeliOliana Carnevali
Apr 19, 2016·Nature·Sigbjørn LienWilliam S Davidson

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Citations

May 22, 2020·Global Change Biology·Nicholas C Wu, Frank Seebacher
Mar 16, 2021·Frontiers in Endocrinology·Fritzie T Celino-BradyAndre P Seale
Jun 16, 2018·Environmental Science & Technology·Jith K ThomasMathilakath M Vijayan

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Datasets Mentioned

BETA
GSE94281

Methods Mentioned

BETA
RNA-Seq
PCA
ubiquitination

Software Mentioned

Cufflinks
R
nlme
multcomp
Blast2GO
lme
Tophat
Bowtie
bcl2fastq
Cuffdiff

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