Bisphenol A increases intestinal permeability through disrupting intestinal barrier function in mice

Environmental Pollution
Ling FengZhigao Chen

Abstract

That an alteration of the intestinal permeability is associated with gut barrier function has been increasingly evident, which plays an important role in human and animal health. Bisphenol A (BPA), an industrial compound used worldwide, has recently been classified as an environmental pollutant. One of our earlier studies has demonstrated that BPA disrupts the intestinal barrier function by inducing apoptosis and inhibiting cell proliferation in the human colonic epithelial cells line. In this study, we investigated the effects of dietary BPA uptake on the colonic barrier function in mice, as well as the intestinal permeability. Dietary BPA uptake was observed to destroy the morphology of the colonic epithelium and increase the pathology score. The levels of endotoxin, diamine peroxidase, D-lactate, and zonulin were found to have been significantly elevated in both plasma and colonic mucosa. A decline in the number of intestinal goblet cells and in mucin 2 gene expression was observed in the mice belonging to the BPA group. The results of immunohistochemistry revealed that the expression of tight junction proteins (ZO-1, occludin, and claudin-1) in colonic epithelium of BPA mice decreased significantly, and their gene abundance...Continue Reading

Citations

Apr 4, 2021·Animals : an Open Access Journal From MDPI·Krystyna Makowska, Slawomir Gonkowski
Aug 8, 2020·Ecotoxicology and Environmental Safety·Wei ZhangLi Xu
Jun 1, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Paulina ŚrednickaMarek Ł Roszko

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