Bisphenol-A induces expression of HOXC6, an estrogen-regulated homeobox-containing gene associated with breast cancer.

Biochimica Et Biophysica Acta
Imran HussainSubhrangsu S Mandal

Abstract

HOXC6 is a homeobox-containing gene associated with mammary gland development and is overexpressed in variety of cancers including breast and prostate cancers. Here, we have examined the expression of HOXC6 in breast cancer tissue, investigated its transcriptional regulation via estradiol (E2) and bisphenol-A (BPA, an estrogenic endocrine disruptor) in vitro and in vivo. We observed that HOXC6 is differentially over-expressed in breast cancer tissue. E2 induces HOXC6 expression in cultured breast cancer cells and in mammary glands of Sprague Dawley rats. HOXC6 expression is also induced upon exposure to BPA both in vitro and in vivo. Estrogen-receptor-alpha (ERα) and ER-coregulators such as MLL-histone methylases are bound to the HOXC6 promoter upon exposure to E2 or BPA and that resulted in increased histone H3K4-trimethylation, histone acetylation, and recruitment of RNA polymerase II at the HOXC6 promoter. HOXC6 overexpression induces expression of tumor growth factors and facilitates growth 3D-colony formation, indicating its potential roles in tumor growth. Our studies demonstrate that HOXC6, which is a critical player in mammary gland development, is upregulated in multiple cases of breast cancer, and is transcriptionally...Continue Reading

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Citations

Jul 26, 2015·Biochimica Et Biophysica Acta·Arunoday Bhan, Subhrangsu S Mandal
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Jun 18, 2019·Journal of Cellular Physiology·Yun GaoTaiyong Yu
Jul 5, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Junyu ZhouXiumei Wang
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Jan 18, 2020·Environmental Health Perspectives·Felicia Fei-Lei Chung, Zdenko Herceg
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Dec 18, 2020·Frontiers in Nutrition·Barbara J StillwaterOrnella I Selmin
Jan 29, 2021·Frontiers in Genetics·Tengfei QinXiangFen Xiao
Mar 10, 2020·Biochimica Et Biophysica Acta. Reviews on Cancer·Simone Aparecida de Bessa GarciaRenata Freitas
Jan 2, 2021·Frontiers in Genetics·Imran HussainSubhrangsu S Mandal
Jun 2, 2021·Gene·Ajay KumarAnil Mukund Limaye

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