Bisphenol A reduces fertilizing ability and motility by compromising mitochondrial function of sperm

Environmental Toxicology and Chemistry
Ram P SinghParappurath A Azeez

Abstract

Bisphenol A (BPA) acts as an endocrine disruptor, affects animal reproductive success in vivo and affects sperm functions in vitro at environmentally relevant concentrations, leading to reduction in sperm motility and fertilizing ability in fish. The effect of in vitro BPA on avian sperm functions has not been explored. The present study examined the effect of environmentally relevant concentrations of BPA (0 mM, 0.18 mM, 0.37 mM, and 0.74 mM) on sperm functions in chicken in vitro. Sperm were exposed to concentrations of BPA for 30 min and analyzed for motility, fertilizing ability, live sperm percentage, and mitochondrial membrane potential (Δψm). Results showed that BPA at a concentration of 0.74 mM significantly decreased motility, fertilizing ability, live sperm count percentage, and sperm Δψm. Sperm motility was positively correlated with fertility (r = 0.73, p ≤ 0.01), live sperm percentage (r = 0.64, p ≤ 0.01), and high Δψm (r = 0.44, p ≤ 0.01). A dose-dependent and time-dependent effect of BPA was observed on sperm motility at all BPA concentrations. However, sperm's fertilizing ability was unaffected in low BPA concentration (0.18 mM and 0.37 mM). A significantly higher percentage of moribund sperm was observed at 0.3...Continue Reading

References

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Sep 24, 2008·Fish Physiology and Biochemistry·Ping LiOtomar Linhart
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Jul 22, 2014·Animal Reproduction Science·C M ShafeequeP A Azeez

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Citations

Feb 20, 2016·Ecotoxicology and Environmental Safety·Ram P SinghParappurath A Azeez
Oct 30, 2016·Reproductive Toxicology·Arcangelo BarbonettiFelice Francavilla
Nov 8, 2018·The Journal of Clinical Endocrinology and Metabolism·Andrea Di NisioCarlo Foresta
Mar 14, 2020·Toxicology Mechanisms and Methods·Elena Herrera-CogcoEsther López-Bayghen
Oct 31, 2017·Environmental Science and Pollution Research International·Ewa Olchowik-GrabarekMaria Zamaraeva
Jul 1, 2020·Frontiers in Endocrinology·Chiara CastelliniArcangelo Barbonetti
Jul 21, 2020·Reproductive Medicine and Biology·Aditi SharmaSuks Minhas

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