Bisphenol A shapes children's brain and behavior: towards an integrated neurotoxicity assessment including human data

Environmental Health : a Global Access Science Source
Vicente Mustieles, Mariana F Fernández

Abstract

Concerns about the effects of bisphenol A (BPA) on human brain and behavior are not novel; however, Grohs and colleagues have contributed groundbreaking data on this topic in a recent issue of Environmental Health. For the first time, associations were reported between prenatal BPA exposure and differences in children's brain microstructure, which appeared to mediate the association between this exposure and children's behavioral symptoms. Findings in numerous previous mother-child cohorts have pointed in a similar worrying direction, linking higher BPA exposure during pregnancy to more behavioral problems throughout childhood as assessed by neuropsychological questionnaires. Notwithstanding, this body of work has not been adequately considered in risk assessment. From a toxicological perspective, results are now available from the CLARITY-BPA consortium, designed to reconcile academic and regulatory toxicology findings. In fact, the brain has consistently emerged as one of the most sensitive organs disrupted by BPA, even at doses below those considered safe by regulatory agencies such as the European Food Safety Authority (EFSA). In this Commentary, we contextualize the results of Grohs et al. within the setting of previous ep...Continue Reading

References

Feb 12, 2009·Journal of Neuroendocrinology·K Wallen, J M Hassett
Sep 4, 2010·Trends in Endocrinology and Metabolism : TEM·Christopher L WrightMargaret M McCarthy
Nov 12, 2014·Proceedings of the National Academy of Sciences of the United States of America·Marija KundakovicFrances A Champagne
Jul 1, 2015·Neurotoxicology·Vicente MustielesMariana F Fernández
Mar 10, 2016·Journal of Exposure Science & Environmental Epidemiology·Maede EjaredarDeborah Dewey
Jul 15, 2016·Environmental Health : a Global Access Science Source·Laura N VandenbergChristina Rudén
Jan 5, 2017·The American Journal of Clinical Nutrition·Qi SunWalter C Willett
May 19, 2017·American Journal of Public Health·Maureen R GwinnThomas A Burke
Mar 8, 2019·Nature Reviews. Endocrinology·Laura N VandenbergAndrea C Gore
Jun 27, 2019·Neurotoxicology·Andrea Rodríguez-CarrilloMariana F Fernández
Jul 10, 2019·Journal of the Endocrine Society·Todd Hagobian
Oct 17, 2019·International Journal of Environmental Research and Public Health·Sarah Lyon-CaenThe Sepages Study Group
Oct 17, 2019·Environmental Health : a Global Access Science Source·Melody N GrohsUNKNOWN APrON Study Team
Feb 26, 2020·Environmental Health : a Global Access Science Source·Francesca PistollatoAnna Bal-Price

❮ Previous
Next ❯

Citations

Jan 19, 2021·Environmental Toxicology and Pharmacology·Ganime AyarPınar Erkekoğlu
Mar 14, 2021·Environmental Health : a Global Access Science Source·Julie Bang HansenTina Kold Jensen
Apr 12, 2021·Diabetes & Metabolic Syndrome·Iram Ashaq KawaFouzia Rashid
Aug 22, 2021·Environmental Research·Viviana RamírezAna Rivas
Nov 19, 2021·Toxicological Sciences : an Official Journal of the Society of Toxicology·Johnathan MorrisMary M Staehle

❮ Previous
Next ❯

Software Mentioned

CLARITY
- BPA
BPA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Lancet. Diabetes & Endocrinology
Kerri Palmer, Valerie Speirs
The Lancet. Diabetes & Endocrinology
Antoine DupuisNicolas Venisse
The Lancet. Diabetes & Endocrinology
Antonia M Calafatadditional coauthors
© 2022 Meta ULC. All rights reserved