Bisphenol S Impaired Human Granulosa Cell Steroidogenesis in Vitro

International Journal of Molecular Sciences
Sarah AmarSébastien Elis

Abstract

Bisphenol S (BPS) is a structural analog of the endocrine disruptor bisphenol A (BPA); it is the main BPA replacement in the plastics industry. Previous studies have shown that BPA and BPS exhibit similar effects on reproduction in fish and rodent species. BPS reportedly alters steroidogenesis in bovine granulosa cells. Luteinised granulosa cells collected from 59 women who were undergoing an in vitro fertilization procedure were cultured for 48 h in the presence or absence of BPS (10 nM, 100 nM, 1 µM, 10 µM or 50 µM). BPS exposure was investigated by assessing follicular fluids from these 59 women for their BPS content. Culture medium, cells, total messenger RNA (mRNA) and total protein extracted from the luteinised granulosa cells were examined for oestradiol and progesterone secretion, cellular proliferation, viability, gene expression, steroidogenic enzyme expression and cell signaling. BPS was measured in follicular fluids using mass spectrometry. Exposure of granulosa cells to 10 or 50 µM BPS for 48 h induced a 16% (p = 0.0059) and 64% (p < 0.0001) decrease, respectively, in progesterone secretion; 50 µM BPS decreased oestradiol secretion by 46% (p < 0.0001). Ten µM BPS also tended to reduce CYP11A1 protein expression by ...Continue Reading

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Citations

Jan 23, 2021·International Journal of Molecular Sciences·Maria E StreetPaola Palanza
Mar 5, 2021·Domestic Animal Endocrinology·G BasiniF Grasselli
Mar 7, 2021·Genes·Reem SabryLaura A Favetta
Jan 10, 2021·Human Reproduction·A TogolaS Elis
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Jun 27, 2021·Toxicology and Applied Pharmacology·Alzbeta Bujnakova Mlynarcikova, Sona Scsukova
Jul 7, 2021·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Ushasi PramanikSaptarshi Mukherjee

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Methods Mentioned

BETA
Assay
enzyme-linked immunosorbent assay
Protein
electrophoresis

Software Mentioned

Ascent Software
Magellan
R
Syngene
lmperm
GeneTools
Targetlynx®
Genesys
Ascent
R Commander package

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