Bisphenols and phthalates: Plastic chemical exposures can contribute to adverse cardiovascular health outcomes.

Birth Defects Research
Manelle RamadanNikki Gillum Posnack

Abstract

Phthalates and bisphenols are high production volume chemicals that are used in the manufacturing of consumer and medical products. Given the ubiquity of bisphenol and phthalate chemicals in the environment, biomonitoring studies routinely detect these chemicals in 75-90% of the general population. Accumulating evidence suggests that such chemical exposures may influence human health outcomes, including cardiovascular health. These associations are particularly worrisome for sensitive populations, including fetal, infant and pediatric groups-with underdeveloped metabolic capabilities and developing organ systems. In the presented article, we aimed to review the literature on environmental and clinical exposures to bisphenols and phthalates, highlight experimental work that suggests that these chemicals may exert a negative influence on cardiovascular health, and emphasize areas of concern that relate to vulnerable pediatric groups. Gaps in our current knowledge are also discussed, so that future endeavors may resolve the relationship between chemical exposures and the impact on pediatric cardiovascular physiology.

References

Apr 1, 1978·Toxicology and Applied Pharmacology·C E AronsonG Preti
Dec 1, 1985·European Journal of Clinical Investigation·P SjöbergJ Gustafsson
Jan 1, 1973·Environmental Health Perspectives·R J Jaeger, R J Rubin
Dec 10, 1998·The Journal of Endocrinology·P Sohoni, J P Sumpter
Jun 28, 2000·Toxicological Sciences : an Official Journal of the Society of Toxicology·G PughJ E Klaunig
Oct 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·A NadalB Soria
Jan 9, 2001·American Journal of Industrial Medicine·J A TicknerM Rossi
May 11, 2002·Environmental Health Perspectives·Jane A HoppinDonna D Baird
Nov 5, 2002·The Journal of Clinical Endocrinology and Metabolism·Kenji MoriyamaKazuwa Nakao
Apr 24, 2003·International Journal of Hygiene and Environmental Health·Holger M KochJürgen Angerer
Apr 15, 2004·Reproductive Toxicology·Céline FioriniGeorges Pointis
Oct 30, 2004·Journal of Toxicology and Environmental Health. Part a·Beom Soo ShinSun Dong Yoo
Mar 5, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Justin G TeeguardenHugh A Barton
Apr 6, 2005·Toxicology and Industrial Health·C S KimJ C Hutter
Apr 7, 2005·Environmental Health Perspectives·Antonia M CalafatLarry L Needham
Jul 12, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Giuseppe Latini
Mar 24, 2006·Nature·Michael C Sanguinetti, Martin Tristani-Firouzi
Apr 6, 2006·Transfusion·Naomi LubanBillie Short
Jul 13, 2006·Risk Analysis : an Official Publication of the Society for Risk Analysis·Matthias WormuthKonrad Hungerbühler
Oct 5, 2006·Human & Experimental Toxicology·Marcela I MartinelliClaudio A Bernal
Dec 22, 2006·International Journal of Hygiene and Environmental Health·Hermann FrommeBernhard Liebl
Jul 14, 2007·Reproductive Toxicology·Yelena B WetherillScott M Belcher
Sep 11, 2007·Reproductive Toxicology·Laura N VandenbergWade V Welshons
Dec 8, 2007·International Journal of Pharmaceutics·Satoshi TakatoriHiroyuki Nakazawa
Jan 17, 2008·Environmental Health Perspectives·Antonia M CalafatLarry L Needham

❮ Previous
Next ❯

Citations

Nov 8, 2020·Nature Reviews. Cardiology·Nikki Gillum Posnack
Aug 8, 2021·Cells·Karolina NowakWioletta Ratajczak-Wrona
Jul 10, 2021·Toxicological Sciences : an Official Journal of the Society of Toxicology·Tomas M PrudencioNikki Gillum Posnack
Sep 25, 2021·Environmental Health Perspectives·Lars LindMartyn T Smith

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.