PMID: 2820524Feb 1, 1987Paper

Bisphosphoglycerate mutase and pyruvate kinase activities during maturation of reticulocytes and ageing of erythrocytes

Bioscience Reports
J LuqueM Pinilla


An increase in bisphosphoglycerate mutase (BPGM) and a decrease in pyruvate kinase (PK), i.e. a decrease in PK/BPGM ratio, was observed in red cell populations from anemic rats containing 95% down to 3% reticulocytes in blood. Such a ratio has been used to study the fractionation of recticulocytes, according to their degree of maturation, after counter-current distribution of those cell populations in dextranpoly (ethylene glycol) two-phase systems. When applying this procedure to the fractionation according to age of erythrocytes from normal rats, the decrease of PK with cellular age was observed without a significant variation in BPGM activity.


Aug 12, 1998·Journal of Chromatography. B, Biomedical Sciences and Applications·A I García-PérezM Pinilla
Sep 22, 2010·Protein Science : a Publication of the Protein Society·Vibhor Gupta, Rameshwar N K Bamezai

Related Concepts

Bisphosphoglycerate Mutase
Erythrocyte Survival
R-Type Pyruvate Kinase

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