Bisphosphonate-induced osteonecrosis of the ear canal: our experience and a review of the literature

The Journal of Laryngology and Otology
L McCaddenW J Primrose

Abstract

Oesophageal disorders and osteonecrosis of the jaw are recognised complications of the commonly prescribed medication bisphosphonate. Despite these diagnoses being seen comparatively frequently within the ENT clinic, osteonecrosis of the external ear is a less well reported complication. The current literature is reviewed and our experience with six cases of bisphosphonate-related ear canal osteonecrosis is presented. Six cases were identified as suffering from ear canal osteonecrosis as a result of bisphosphonate treatment. One of our cases suffered bilateral ear canal osteonecrosis after only 20 months of oral alendronic acid treatment. Management ranged from bisphosphonate cessation and topical treatment, to surgical debridement in the operating theatre. Bisphosphonate-related ear canal osteonecrosis is undoubtedly under-diagnosed. For such a commonly prescribed medication, the risks and side effects of bisphosphonate should be better known and long-term treatment should be avoided if possible.

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Citations

Aug 3, 2018·Head and Neck Pathology·Amarpreet SabharwalMichelle D Williams
Aug 3, 2018·Head and Neck Pathology·Kelly R MaglioccaChristopher C Griffith
Feb 7, 2019·Current Osteoporosis Reports·Clare E Yellowley, Damian C Genetos
Aug 28, 2020·International Journal of Molecular Sciences·Yongguang GaoAirong Qian
Sep 7, 2018·Der Radiologe·V Hingst, M-A Weber
Feb 2, 2021·Journal of Medicinal Chemistry·Jéssica S BarbosaSusana Santos Braga
Mar 2, 2021·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Raimund H M PreidlFalk Wehrhan
Jun 17, 2021·BMJ Case Reports·Harry David TrueJoel Anthony Smith
Jul 28, 2020·Auris, Nasus, Larynx·Takamori TakedaTakeshi Tsutsumi

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