Bisphosphonate-loaded Bone Cement as a Local Adjuvant Therapy for Giant Cell Tumor of Bone: A 1 to 12-Year Follow-up Study

American Journal of Clinical Oncology
David D Greenberg, Francis Young-In Lee

Abstract

Historically, nontargeted adjuvant therapies such as liquid nitrogen, phenol, argon beam, and alcohol have been applied locally after curettage of giant cell tumors (GCT) in the extremities. Systemic bisphosphonates (BP) and denosumab have emerged as osteoclast-targeting therapies because osteoclast-like giant cells, responsible for aggressive bone resorption, are susceptible to BP or denosumab. However, such drugs may cause systemic side effects. We examined the effects of an alternative intraoperative local delivery of BP on GCTs. In total, 17 patients with GCTs underwent extended surgical curettage procedures consisting of high-speed burring, traditional adjuvant therapy, and application of BP-loaded polymethylmethacrylate bone cement. Clinical data and follow-up radiographs were reviewed to investigate local recurrence (LR) rate and complications in a retrospective manner. There were 6 males and 11 females (mean age, 33.7 y). There were no cases of pulmonary metastases. Patient follow-up ranged from 1 to 12 years. There was 1 LR during the follow-up period for an LR rate of 5.9%. The mean final Musculoskeletal Tumor Society (MSTS) score was 29. There were no systemic or localized avascular necrosis or atypical fractures rel...Continue Reading

References

Jan 20, 1999·Annals of the Rheumatic Diseases·A SabokbarN A Athanasou
Mar 17, 1999·Clinical Orthopaedics and Related Research·M M MalawerY Kollender
Nov 11, 1999·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·H R DürrH J Refior
Feb 24, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P MajorJ Seaman
Aug 15, 2001·Journal of Cancer Research and Clinical Oncology·M WüllingE Kaiser
Apr 16, 2002·Clinical Orthopaedics and Related Research·Robert E TurcotteUNKNOWN Canadian Sarcoma Group
Mar 24, 2004·Calcified Tissue International·Y Y ChengS M Kumta
Sep 4, 2004·Clinical Orthopaedics and Related Research·Seong Sil ChangFrancis Young-In Lee
Dec 21, 2004·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Ted S LiaoFrancis Young-In Lee
Sep 8, 2006·Clinical Orthopaedics and Related Research·Valerae O LewisMichael A Simon
May 3, 2008·The Journal of Bone and Joint Surgery. American Volume·UNKNOWN Arbeitsgemeinschaft KnochentumorenPer-Ulf Tunn
May 29, 2008·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Nicole Y C YuAaron Schindeler
Nov 3, 2009·Cancer Treatment Reviews·Costantino ErraniMario Mercuri
Jan 6, 2010·The Journal of Bone and Joint Surgery. American Volume·Pawel ZwolakEdward Y Cheng
Aug 14, 2010·Clinical Orthopaedics and Related Research·Frank M KlenkeFranklin H Sim
Sep 22, 2010·Clinical Orthopaedics and Related Research·Frank M KlenkeFranklin H Sim
Jul 7, 2011·Clinical Orthopaedics and Related Research·Wei-Hsin LinRong-Sen Yang
Jun 5, 2012·Clinics in Orthopedic Surgery·Yuhree KimFrancis Y Lee
Jul 10, 2012·Clinical Orthopaedics and Related Research·Yu-Peng LiuBu-Hua Sun
Feb 5, 2013·The Journal of the American Academy of Orthopaedic Surgeons·Kevin A RaskinFrancis J Hornicek
Jun 27, 2013·Indian Journal of Orthopaedics·Zile Singh KunduParveen Rana

❮ Previous
Next ❯

Citations

May 27, 2020·Current Opinion in Oncology·Lizz van der HeijdenHans Gelderblom
Jul 6, 2020·Current Treatment Options in Oncology·Emanuela PalmeriniR Lor Randall
Aug 8, 2021·Cancers·Shinji TsukamotoCostantino Errani
Aug 28, 2021·Cancers·Adrian Emilian BădilăAdrian Radu Rădulescu

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Software Mentioned

MSTS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.