Bisphosphonates induce apoptosis of circulating endothelial cells in multiple myeloma patients and in subjects with bisphosphonate-induced osteonecrosis of the jaws

Acta Haematologica
Alessandro AllegraCaterina Musolino

Abstract

Bisphosphonates (BPs) are the current standard of care for bone lesions in patients with multiple myeloma (MM) but they are associated with a number of side effects such as osteonecrosis of the jaw. The exact mechanisms of osteonecrosis are not elucidated, and its physiopathology is based on several hypotheses such as a decrease in bone remodeling or an inhibitory effect on angiogenesis. The aim of our study was to investigate the mechanism involved in the pathogenesis of osteonecrosis. We examined the apoptosis of circulating endothelial progenitor cells in MM subjects before and after BP treatment and in osteonecrosis patients using a flow-cytometric analysis. Our data showed an increase in endothelial cell apoptosis in MM patients after BP administration and in osteonecrosis subjects. Our study seems in agreement with the hypothesis that BPs can inhibit angiogenesis interfering with endothelial cell proliferation and survival, leading to loss of blood vessels and avascular necrosis.

Citations

Jul 10, 2013·Calcified Tissue International·Gemma MarcucciMaria Luisa Brandi
Jun 27, 2013·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Alessandro AllegraCaterina Musolino
Feb 10, 2016·Scientific Reports·Dileep SharmaSaso Ivanovski
Apr 20, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Isaac M AdjeiVinod Labhasetwar
Dec 31, 2011·Clinical Lymphoma, Myeloma & Leukemia·Gerrard TeohYeo-Kyeoung Kim
Jan 15, 2014·Allergologia et immunopathologia·Paola Lucia MinciulloSebastiano Gangemi
Apr 15, 2016·Expert Opinion on Drug Safety·V FuscoG Campisi
Dec 6, 2014·Journal of Dental Research·A Peer, M Khamaisi
Dec 24, 2014·Journal of Dental Research·Y NagaokaK Okabe
Feb 18, 2018·Clinical Oral Investigations·Jean-Daniel Kün-DarboisDaniel Chappard
Jan 9, 2018·The Journal of Craniofacial Surgery·Luyao QuBaoli Wang
Oct 28, 2018·Pharmaceutics·Isaac M AdjeiBlanka Sharma
May 14, 2019·The Tohoku Journal of Experimental Medicine·Alessandro AllegraCaterina Musolino
Mar 31, 2017·Molecular and Clinical Oncology·Daigo YamamotoMasanori Kon
Sep 1, 2017·The Journal of Craniofacial Surgery·Enrico Nastro SiniscalchiMarco Cicciù
Nov 9, 2016·Dentistry Journal·Yong-Dae Kwon, Deog-Yoon Kim
Aug 23, 2020·Journal of Stomatology, Oral and Maxillofacial Surgery·A CerratoC Bacci

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